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N-1-Naphthalenyl-1-pentyl-1H-indole-3-carboxamide

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Name

N-1-Naphthalenyl-1-pentyl-1H-indole-3-carboxamide

EINECS N/A
CAS No. 1338925-11-3 Density 1.12±0.1 g/cm3 (20 oC 760 Torr), Calc.*
PSA 34.03000 LogP 6.31000
Solubility Insuluble (4.3E-5 g/L) (25 oC), Calc.* Melting Point N/A
Formula C24H24N2O Boiling Point N/A
Molecular Weight 356.467 Flash Point N/A
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 1338925-11-3 (1-pentyl-N-(naphthalen-1-yl)-1H-indole-3-carboxamide) Hazard Symbols N/A
Synonyms

MN-24;

Article Data 1

N-1-Naphthalenyl-1-pentyl-1H-indole-3-carboxamide Synthetic route

1338925-20-4

methyl 1-pentyl-1H-indole-3-carboxylate

134-32-7

1-amino-naphthalene

1338925-11-3

N-(naphthalen-1-yl)-1-pentyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Stage #1: 1-amino-naphthalene With trimethylaluminum In 1,2-dichloro-ethane; toluene at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: methyl 1-pentyl-1H-indole-3-carboxylate In 1,1,1-trichloroethane; toluene for 24h; Inert atmosphere; Reflux;
85%
942-24-5

3-methoxycarbonylindole

1338925-11-3

N-(naphthalen-1-yl)-1-pentyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
2.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0.17 h / 20 °C / Inert atmosphere
2.2: 24 h / Inert atmosphere; Reflux
View Scheme
110-53-2

1-Bromopentane

1338925-11-3

N-(naphthalen-1-yl)-1-pentyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C / Inert atmosphere
2.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0.17 h / 20 °C / Inert atmosphere
2.2: 24 h / Inert atmosphere; Reflux
View Scheme

N-1-Naphthalenyl-1-pentyl-1H-indole-3-carboxamide Specification

N-1-Naphthalenyl-1-pentyl-1H-indole-3-carboxamide is a novel indole and azaindole cannabinoid receptor agonists.

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