N-Iodosuccinimide Synthetic route
ConditionsConditions | Yield |
---|
With [bis(acetoxy)iodo]benzene; iodine In benzene at 20℃; for 15h; Concentration; Solvent; Time; Darkness; | 99% |
With Iodine monochloride; bis(tri-n-butyltin)oxide 1.) benzene, reflux, 4 h, 2.) CH3CN; Yield given. Multistep reaction; | |
ConditionsConditions | Yield |
---|
With sodium iodide In acetone for 0.25h; | 89% |
With sodium iodide In acetone for 2h; | 44% |
With sodium iodide In acetone for 0.25h; | |
With sodium iodide In N,N-dimethyl-formamide at 20℃; for 1h; | |
With sodium iodide In acetone for 0.25h; | |
ConditionsConditions | Yield |
---|
With iodine In tetrachloromethane at 40 - 50℃; for 1h; | 80% |
With iodine In (2)H8-toluene at 20℃; | |
With iodine In tetrachloromethane at 40 - 55℃; | |
ConditionsConditions | Yield |
---|
Ausgangstoff ist Succinimid-silber; | |
- mercury comp bond of succinimide
mercury comp bond of succinimide
ConditionsConditions | Yield |
---|
With acetic acid ester; iodine | |
- silver compound of succinimide
silver compound of succinimide
ConditionsConditions | Yield |
---|
With iodine; acetone | |
With diethyl ether; iodine | |
- silver-compound of succinimide
silver-compound of succinimide
ConditionsConditions | Yield |
---|
With iodine; ethyl acetate | |
With iodine; acetone | |
With 1,4-dioxane; iodine | |
ConditionsConditions | Yield |
---|
In tetrahydrofuran Nb-complex was dissolved in THF, ligand was added, shaken for 5 min under inert atm.; after 10 min solvent was removed by rotary evaporator, residue was redissolved in CH2Cl2, flash-chromd. on silica, solvent was removed; elem. anal.; | 100% |
(η5-C5H5)Co(Et2C2B3H5)
(C5H5)Co((C2H5)2C2B3H3I2)
ConditionsConditions | Yield |
---|
In not given inert atmosphere; | 100% |
(C5(CH3)5)Co((CH3CH2)2C2B3H4Br)
(η(5)-C5Me5)Co(2,3-Et2C2B3H3-4-Br-6-I)
ConditionsConditions | Yield |
---|
In tetrahydrofuran inert atmosphere; stirring (15 min); evapn., chromy. (SiO2, hexane); | 100% |
N-Iodosuccinimide Chemical Properties
Molecular Structure of N-Iodosuccinimide (CAS NO.516-12-1):
IUPAC Name: 1-iodopyrrolidine-2,5-dione
Empirical Formula: C4H4INO2
Molecular Weight: 224.9845
Index of Refraction: 1.653
Surface Tension: 62.4 dyne/cm
Density: 2.31 g/cm3
Flash Point: 104.8 °C
Enthalpy of Vaporization: 48.69 kJ/mol
Boiling Point: 249.6 °C at 760 mmHg
Vapour Pressure: 0.0227 mmHg at 25°C
storage temp.:2-8°C
Water Solubility: decomposes
Synonyms of N-Iodosuccinimide (CAS NO.516-12-1): 1-Iodo-2,5-pyrrolidinedione ; nis;n-iodosuccinimide ; 1-iodo-5-pyrrolidinedione ; n-iodo-succinimid ; succinimide,n-iodo- ; succiniodimide ; 1-iodopyrrolidine-2,5-dione
N-Iodosuccinimide Toxicity Data With Reference
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02815, |
N-Iodosuccinimide Safety Profile
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
N-Iodosuccinimide Specification
N-Iodosuccinimide (CAS NO.516-12-1) is a white-yellow to brown crystalline powder,be sensitive to water and ligh.In organic synthesis for ketones, aldehydes of iodide, primarily as a pharmaceutical intermediates in the biological drug, its production method is without light conditions, in reaction of succinimide and silver oxide, Preparation N-succinic imide silver, in dry dioxane in the reaction ti get N-iodo succinimide.