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N-Methyl-D-Glucamine
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Name

N-Methyl-D-Glucamine

 EINECS 228-506-9
CAS No. 6284-40-8 Density 1.375 g/cm3
PSA 113.18000 LogP -2.96740
Solubility 100 g/100 mL (25 ºC) Melting Point 129-131.5 °C(lit.)
Formula C7H17NO5 Boiling Point 490.4 °C at 760 mmHg
Molecular Weight 195.216 Flash Point 251.6 °C
Transport Information N/A Appearance white to almost white crystalline powder
Safety 24/25 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 6284-40-8 (Meglumine) Hazard Symbols N/A
Synonyms

Glucitol,1-deoxy-1-(methylamino)-, D- (8CI);Sorbitol, 1-deoxy-1-methylamino- (6CI);1-Deoxy-1-(methylamino)-D-glucitol;D-(-)-N-Methylglucamine;Meglumin;Meglumine;Methylglucamin;Methylglucamine;N-Methyl-D(-)-glucamine;N-Methylglucamine;N-Methylsorbitylamine;NSC 52907;NSC 7391;

Article Data 34

N-Methyl-D-Glucamine Synthetic route

24758-59-6

N-methyl-D-gluconamide

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

Conditions
ConditionsYield
With ammonia borane; palladium/alumina at 78℃; under 975.098 - 48004.8 Torr; for 2h; Temperature; Pressure; Reagent/catalyst; Inert atmosphere; Large scale;69.3%
50-99-7

D-glucose

74-89-5

methylamine

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

Conditions
ConditionsYield
With hydrogen In water at 10 - 100℃; under 5171.62 - 25858.1 Torr; for 21.5h;62.5%
With nickel kieselguhr; water at 95 - 120℃; under 36775.4 - 102971 Torr; Hydrogenation;
With ethanol Hydrierung des Reaktionsprodukts an Palladium-Kohle in Methanol bei 60grad/20-25at;
50-99-7

D-glucose

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

Conditions
ConditionsYield
With methylamine
50-99-7

D-glucose

3400-38-2

methylaminomethanol

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

557-04-0

magnesium stearate

A

poloxamer

poloxamer

B

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

50-99-7

D-glucose

74-89-5

methylamine

A

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

B

110-70-3

N,N`-dimethylethylenediamine

Conditions
ConditionsYield
With 5 wt% ruthenium/carbon; hydrogen In water at 124.84℃; under 56255.6 Torr; for 1h;

5-({4-[(4-butylphenyl)ethynyl]benzyl}{[2-(ethoxycarbonyl)cyclopropyl]methyl}amino)-2-fluorobenzoic acid

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

5-({4-[(4-butylphenyl)ethynyl]benzyl}{[2-(ethoxycarbonyl)cyclopropyl]methyl}amino)-2-fluorobenzoic acid N-methyl-D-glucamine salt

Conditions
ConditionsYield
In methanol; water100%

gadolinium(III) oxide

124628-06-4

2-[1,4,7,10-tetraaza-4,7-di(1-carboxy-2-benzyloxy-ethyl)-10-carboxymethyl-cyclododecane-1-yl]-3-benzyloxypropionic acid

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

{gadolinium(C8H17N4(CH2COO)(CH(COO)CH2OCH2C6H5)3)(D(-)-N-methylglucamine)}

Conditions
ConditionsYield
In water heating to 70°C until a clear soln. was obtained; evapn. (vac.) and isolation after drying to const. weight; elem. anal.;100%

gadolinium(III) oxide

124628-02-0

2-[1,4,7,10-tetraaza-4-(1-carboxy-2-benzyloxy-ethyl)-7,10-di(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

{gadolinium(C8H17N4(CH2COO)2(CH(COO)CH2OCH2C6H5)2)(D(-)-N-methylglucamine)}

Conditions
ConditionsYield
In water heating to 70°C until a clear soln. was obtained; evapn. (vac.) and isolation after drying to const. weight; elem. anal.;100%

gadolinium(III) oxide

124628-08-6

2-[1,4,7,10-tetraaza-4,7,10-tri(carboxymethyl)-cyclododecane-1-yl]-3-benzyloxypropionic acid

6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

{gadolinium(C8H17N4(CH2COO)3CH(COO)CH2OCH2C6H5)(D(-)-N-methylglucamine)}

Conditions
ConditionsYield
In water heating to 70°C until a clear soln. was obtained; evapn. (vac.) and isolation after drying to const. weight; elem. anal.;100%

N-Methyl-D-Glucamine Specification

N-Methyl-D-Glucamine , with the CAS register number 6284-40-8, is also known as 1-deoxy-1-(methylamino)-d-glucito;1-deoxy-1-(methylamino)hexitol ; glucitol, 1-deoxy-1-(methylamino)-, d- ; meglumin ; methylglucamin ; methylglucamine ; d-glucitol, 1-deoxy-1-(methylamino)- ; d(-)-n-methylglucamine .

The characteristics of this kind of chemical are as below: (1)#H bond acceptors:  6  ; (2)#H bond donors:  6  ; (3)#Freely Rotating Bonds:  11  ; (4)Polar Surface Area:  49.39   ; (5)Index of Refraction:  1.555  ; (6)Molar Refractivity:  45.58 cm3  ; (7)Molar Volume:  141.9 cm3  ; (8)Polarizability:  18.07 ×10-24cm3  ; (9)Surface Tension:  70.8 dyne/cm  ; (10)Density:  1.375 g/cm3  ; (11)Flash Point:  251.6 °C  ; (12)Enthalpy of Vaporization:  87.2 kJ/mol  ; (13)Boiling Point:  490.4 °C at 760 mmHg  ; (14)Vapour Pressure:  1.12E-11 mmHg at 25°C  .

It is white to almost white crystalline powder. It is soluble in the H2O: 0.1 g/mL(clear, colorless liquid) while in the water 100 g/100 mL (25 ºC). The raw materials are acetaldehyde ammonia and 1-glucose-methylamine schiffbase . Beside, it is sensitive to air and hygroscopic.

Being a kind of irritant chemical, it is harmful to eyes, respiratory system and skin. And while using this chemical, remember to avoid contacting with skin and eyes. If you need more safety information, you could refer to the WGK Germany  3. When it comes to storing method, it should be kept under argon and in a dry place.

N-Methyl-D-Glucamine's product categories are in the below listing of anilines, aromatic amines and nitro compounds, aminosugars, biochemistry, and sugars. As for its uage, it is usualy used as the cosolvent and the surface active agent for contrast agent. We could make it as the following steps:
condense glucose and Monomethylamine and then have the catalytic hydrogenation, finally, you could get  this chemical.

In addition, you could obtain the molecular structure by converting the following data information:
SMILES:O[C@H]([C@@H](O)CNC)[C@H](O)[C@H](O)CO
InChI:InChI=1/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1
InChIKey:MBBZMMPHUWSWHV-BDVNFPICBL

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