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N-Nitrosodiethylamine

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Name

N-Nitrosodiethylamine

EINECS 200-226-1
CAS No. 55-18-5 Density 0.95g/cm3
PSA 32.67000 LogP 1.00960
Solubility substantial

Stability

    Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents,reducing agents.

Toxicology

    Harmful if swallowed. Experimental carcinogen, teratogen, mutagen.May c
Melting Point <25℃
Formula C4H10 N2 O Boiling Point 173.9°Cat760mmHg
Molecular Weight 102.136 Flash Point 59°C
Transport Information N/A Appearance yellow liquid
Safety Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES.

Analytical Methods:

   

For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines, 2522.

Risk Codes R45; R22; R39/23/24/25; R23/24/25; R11
Molecular Structure Molecular Structure of 55-18-5 (N-NITROSODIETHYLAMINE) Hazard Symbols T,F
Synonyms

Diethylamine,N-nitroso- (6CI,8CI); DEN; DEN (mutagen); DENA; Diethylnitrosamide;Diethylnitrosamine; Diethylnitrosoamine; N,N-Diethylnitrosoamine;N-Ethyl-N-nitrosoethanamine; N-Nitroso-N,N-diethylamine; N-Nitrosodiethylamine;NDEA; NSC 132; Nitrosodiethylamine

Article Data 97

N-Nitrosodiethylamine Synthetic route

109-89-7

diethylamine

55-18-5

N-Nitrosodiethylamine

Conditions
ConditionsYield
With [NO(1+)*18-crown-6*H(NO3)2(1-)] In dichloromethane at 20℃; for 0.0833333h;100%
With magnesium hydrogen sulfate; silica gel; sodium nitrite In dichloromethane at 20℃; for 1h; Nitrosation;98%
With aluminium trichloride; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.5h; Nitrosation;98%
121-44-8

triethylamine

55-18-5

N-Nitrosodiethylamine

Conditions
ConditionsYield
With tin(IV) chloride; sodium nitrite In tetrachloromethane for 14h; Heating;96%
With bromine; triphenylphosphine In dichloromethane at 20℃; for 0.0166667h;92%
With dinitrogen tetroxide impregnated on activated charcoal In tetrachloromethane for 10h; Heating;85%
660-68-4

diethyl amine hydrochloride

55-18-5

N-Nitrosodiethylamine

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water at 70 - 75℃; for 3h; Inert atmosphere;68%
With citrate buffer; sodium nitrite In acetone at 37℃; for 4h;
With sodium nitrite In acetone at 37℃; for 4h; effect of varios organic solvents;
With sodium nitrite In water at 37℃; for 4h; inhibitory effect of organic and inorganic salts;
109-89-7

diethylamine

A

55-18-5

N-Nitrosodiethylamine

B

125227-79-4

C4H10FN

Conditions
ConditionsYield
With trifluoroamine oxide at -10℃; for 1.5h;A 30%
B 45%
110-86-1

pyridine

509-14-8

tetranitromethane

121-44-8

triethylamine

55-18-5

N-Nitrosodiethylamine

34155-23-2

N1,N1,N3,N3-tetraethyl-propane-1,2,3-triyltriamine

A

N1,N1,N3,N3-tetraethyl-N2-nitroso-propane-1,2,3-triyltriamine

B

55-18-5

N-Nitrosodiethylamine

Conditions
ConditionsYield
With cis-nitrous acid
27096-30-6

diethylammonium, NO3(1-)-salt

55-18-5

N-Nitrosodiethylamine

Conditions
ConditionsYield
at 170℃;
75-04-7

ethylamine

55-18-5

N-Nitrosodiethylamine

Conditions
ConditionsYield
With diethyl ether; nitrosylchloride at -20 - -15℃;
64-17-5

ethanol

509-14-8

tetranitromethane

64-19-7

acetic acid

121-44-8

triethylamine

55-18-5

N-Nitrosodiethylamine

Conditions
ConditionsYield
at 100℃;
at 100℃;
88-10-8

N,N-diethylcarbamyl chloride

A

55-18-5

N-Nitrosodiethylamine

B

7119-92-8

diethyl-N-nitroamine

Conditions
ConditionsYield
With silver nitrate; acetonitrile

N-Nitrosodiethylamine Chemical Properties

Empirical Formula: C4H10N2O
Molecular Weight: 102.135 g/mol
EINECS: 200-226-1 
Index of Refraction: 1.442
Density: 0.95 g/cm3
Flash Point: 59 °C
Enthalpy of Vaporization: 39.34 kJ/mol
Boiling Point: 173.9 °C at 760 mmHg
Vapour Pressure: 1.66 mmHg at 25 °C 
Storage tempreture: 2-8 °C
Appearance: Clear slightly yellow liquid
Form: Liquid
Color: Yellow
Stable: Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.
Structure of N-Nitrosodiethylamine (CAS NO.55-18-5):
          
IUPAC Name: N,N-Diethylnitrous amide
Product Categories of N-Nitrosodiethylamine (CAS NO.55-18-5): Nitrosamine
 

N-Nitrosodiethylamine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 175mg/kg (175mg/kg)   Carcinogenesis Vol. 5, Pg. 533, 1984.
guinea pig LD50 oral 250mg/kg (250mg/kg)   Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.
hamster LD50 subcutaneous 232mg/kg (232mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BLOOD: OTHER CHANGES
LIVER: OTHER CHANGES
British Journal of Cancer. Vol. 33, Pg. 411, 1976.
hamster LD50 unreported 246mg/kg (246mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
LIVER: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER"
Journal of the National Cancer Institute. Vol. 49, Pg. 595, 1972.
mouse LD50 intramuscular 356mg/kg (356mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973.
mouse LD50 intraperitoneal 132mg/kg (132mg/kg)   JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
mouse LD50 intravenous 293mg/kg (293mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973.
mouse LD50 oral 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) National Technical Information Service. Vol. OTS0555387,
mouse LD50 unreported 210mg/kg (210mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980.
rat LD50 intraperitoneal 216mg/kg (216mg/kg)   Biochemical Journal. Vol. 85, Pg. 72, 1962.
rat LD50 intravenous 280mg/kg (280mg/kg)   IARC Scientific Publications. Vol. 4, Pg. 45, 1973.
rat LD50 oral 220mg/kg (220mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
LIVER: FATTY LIVER DEGERATION
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1167, 1964.
rat LD50 subcutaneous 195mg/kg (195mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
LIVER: OTHER CHANGES
Experimental Pathology Vol. 27, Pg. 171, 1985.
rat LD50 unreported 245mg/kg (245mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980.

N-Nitrosodiethylamine Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 107.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) , IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 28 ,1982,p. 151.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 17 ,1978,p. 83.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Clear Evidence: mouse, rat RRCRBU    Recent Results in Cancer Research. 52 (1975),1. . Reported in EPA TSCA Inventory. Community Right-To-Know List.

N-Nitrosodiethylamine Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES.
Hazard Codes of N-Nitrosodiethylamine (CAS NO.55-18-5): ToxicT,FlammableF
Risk Statements: 45-22-39/23/24/25-23/24/25-11 
R11:Highly flammable. 
R22:Harmful if swallowed. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R39:Danger of very serious irreversible effects. 
R45:May cause cancer.
Safety Statements: 53-45-36/37-16 
S16:Keep away from sources of ignition. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use.

N-Nitrosodiethylamine Standards and Recommendations

DFG MAK: Animal Carcinogen, Suspected Human Carcinogen

N-Nitrosodiethylamine Analytical Methods

For occupational chemical analysis use OSHA: #27 or NIOSH: Nitrosamines, 2522.

N-Nitrosodiethylamine Specification

 N-Nitrosodiethylamine ,its cas register number is 55-18-5. It also can be called Nitrosodiethylamine ; N-ethyl-N-nitrosoethanamine ; Ethanamine, N-ethyl-N-nitroso- ;and Diethylnitrosamine . N-Nitrosodiethylamine (CAS NO.55-18-5) reacts with strong oxidizing agents, and can be hydrolyzed by hydrogen bromide in acetic acid .

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