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Name	N-Phenylpiperidin-4-amine	EINECS	N/A
CAS No.	23056-29-3	Density	1.052g/cm³
PSA	24.06000	LogP	2.25230
Solubility	N/A	Melting Point	N/A
Formula	C11H16 N2	Boiling Point	312°Cat760mmHg
Molecular Weight	176.261	Flash Point	185.3°C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Piperidine,4-anilino- (8CI); 4-Anilinopiperidine; N-(Piperidin-4-yl)aniline;N-Phenylpiperidin-4-amine; NSC 80678	Article Data	10

N-Phenylpiperidin-4-amine Synthetic route

: 125541-22-2
1-(tert-butoxycarbonyl)-4-phenylaminopiperidine

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 1h;	100%
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 3h;	86%
With trifluoroacetic acid In dichloromethane

: 116512-92-6
N-(1-ethoxycarbonyl-4-piperidinyl)aniline

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
With hydrogenchloride In water for 16h; Heating;	92%

: 13035-19-3
4-aminopiperidine

: 108-90-7
chlorobenzene

A: 63921-23-3
1-phenylpiperidin-4-ylamine

B: 1-phenyl-4-(phenylamino)piperidine

C: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
With sodium t-butanolate; DavePhos; tris-(dibenzylideneacetone)dipalladium(0) In xylene at 130℃; for 24h;	A 60% B 7% C n/a

: 13035-19-3
4-aminopiperidine

: 108-86-1
bromobenzene

A: 63921-23-3
1-phenylpiperidin-4-ylamine

B: 1-phenyl-4-(phenylamino)piperidine

C: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
With chiral ferrocene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) In xylene at 130℃; for 24h; Product distribution; Further Variations:; Reagents;	A 18% B 8% C 15%

: 62-53-3
aniline

ethane-α.β-bis-sulfonic acid chloride: ethane-α.β-bis-sulfonic acid chloride

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) molecular sieves; 2) NaBH4 / 1) benzene, reflux, 20 h; 2) EtOH, room temp., 5 h 2: 92 percent / 6 N aq. HCl / H2O / 16 h / Heating View Scheme

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) molecular sieves; 2) NaBH4 / 1) benzene, reflux, 20 h; 2) EtOH, room temp., 5 h 2: 92 percent / 6 N aq. HCl / H2O / 16 h / Heating View Scheme

: 41979-39-9
4-piperidone hydrochloride

: 62-53-3
aniline

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Stage #1: 4-piperidone hydrochloride; aniline With acetic acid; zinc at 20 - 70℃; for 24h; Stage #2: With sodium hydroxide In water Product distribution / selectivity; Cooling with ice;

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme

: 62-53-3
aniline

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme

: 41979-39-9
4-piperidone hydrochloride

: 23056-29-3
phenyl-piperidin-4-yl-amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 24 h / 20 °C 2: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C 3: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme

N-Phenylpiperidin-4-amine Chemical Properties

Molecular Structure of N-Phenyl-4-piperidinamine (CAS NO.23056-29-3):

IUPAC Name: N-phenylpiperidin-4-amine
Empirical Formula: C₁₁H₁₆N₂
Molecular Weight: 176.2581
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 24.06 Å²
Index of Refraction: 1.579
Molar Refractivity: 55.634 cm³
Molar Volume: 167.427 cm³
Surface Tension: 42.068 dyne/cm
Density: 1.053 g/cm³
Flash Point: 185.298 °C
Enthalpy of Vaporization: 55.297 kJ/mol
Boiling Point: 312.012 °C at 760 mmHg
Vapour Pressure: 0.001 mmHg at 25°C
InChI
InChI=1/C11H16N2/c1-2-4-10(5-3-1)13-11-6-8-12-9-7-11/h1-5,11-13H,6-9H2
Smiles
N1CCC(Nc2ccccc2)CC1

N-Phenylpiperidin-4-amine Safety Profile

HazardClass: Irritant

N-Phenylpiperidin-4-amine Specification

N-Phenyl-4-piperidinamine , with CAS number of 23056-29-3, can be called 4-piperidinamine, N-phenyl- ; N-phenylpiperidin-4-amine .