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| Name |
NOVOBIOCIN, MONOSODIUM SALT |
EINECS | N/A |
| CAS No. | 1476-53-5 | Density | 1.42g/cm3 |
| PSA | 202.84000 | LogP | 4.83860 |
| Solubility | Soluble in water at 100mg/ml. Also soluble in ethanol or DMSOSoluble in water, ethanol, dimethyldulfoxide and methanol. | Melting Point |
215-220oC |
| Formula | C31H36 N2 O11 . Na | Boiling Point | 848.2°Cat760mmHg |
| Molecular Weight | 634.615 | Flash Point | 466.8°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O. | Risk Codes | 43-36 |
| Molecular Structure |
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Hazard Symbols |
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| Synonyms |
Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-,monosodium salt (9CI); Novobiocin, monosodium salt (8CI); Novobiocin, sodiumderiv. (6CI,7CI); Albamycin; Albamycin (capsule); Albamycin sodium; Cathomycinsodium; Cathomycin sodium lyovac; Monosodium novobiocin; NSC 2382; Novobiocinmonosodium; Novobiocin sodium; Novobiocin sodium salt; Sodium albamycin; Sodiumnovobiocin; Vulcamycin |
NOVOBIOCIN, MONOSODIUM SALT Chemical Properties
Product Name: Novobiocin, monosodium salt (1476-53-5)
Molecular Formula: C31H35N2NaO11
Molecular Weight: 634.61g/mol
Mol File: 1476-53-5.mol
Einecs: 216-023-6
Melting Point: 215-220 °C
Boiling point: 848.2°C at 760mmHg
Storage Temperature: 2-8°C
Flash Point: 466.8°C
Density: 1.42g/cm3
Product Categories: Coumarin-glycosidesAntibiotics ; Antibacterial ; Antibiotics ; Antibiotics A to ; Antibiotics by Application ; Antibiotics N-SAntibiotics ; Antineoplastic and Immunosuppressive AntibioticsAntibiotics ; Chemical Structure Class ; Inhibits an EnzymeAntibiotics ; Interferes with DNA SynthesisSpectrum of Activity ; L - ZMore...Close...; Mechanism of Action
Synonyms of Novobiocin, monosodium salt (1476-53-5): albamycin(capsule) ; Albamycinsodium ; Cathomycinsodium ; Cathomycinsodiumlyovac ; Monosodiumnovobiocin ; Novobiocin,sodiumderiv. ; Novobiocinmonosodium ; Sodiumalbamycin.
NOVOBIOCIN, MONOSODIUM SALT Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intraperitoneal | 12mg/kg (12mg/kg) | "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971. | |
| guinea pig | LD50 | subcutaneous | 28mg/kg (28mg/kg) | "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971. | |
| mouse | LD50 | intraperitoneal | 262mg/kg (262mg/kg) | Antibiotics and Chemotherapy Vol. 6, Pg. 226, 1956. | |
| mouse | LD50 | intravenous | 407mg/kg (407mg/kg) | Antibiotics and Chemotherapy Vol. 6, Pg. 226, 1956. | |
| mouse | LD50 | oral | 962mg/kg (962mg/kg) | Antibiotics and Chemotherapy Vol. 6, Pg. 226, 1956. | |
| mouse | LD50 | subcutaneous | 395mg/kg (395mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958. | |
| rat | LD50 | intravenous | 385mg/kg (385mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958. | |
| rat | LD50 | oral | 3500mg/kg (3500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958. | |
| rat | LD50 | subcutaneous | 450mg/kg (450mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 386, 1958. |
NOVOBIOCIN, MONOSODIUM SALT Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also promote the development of resistant strains of staphylococcus. When heated to decomposition it emits toxic fumes of NOx and Na2O.
Safety Information of Novobiocin, monosodium salt (1476-53-5):
Hazard Codes: Xi,Xn.gif){kind=small}
Risk Statements: 43-36-36/37/38-20/21/22
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
43: May cause sensitization by skin contact
Safety Statements: 36-36/37-26-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
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