Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
Nandrolone phenylpropionate |
EINECS | 200-551-9 |
CAS No. | 62-90-8 | Density | 1.14 g/cm3 |
PSA | 43.37000 | LogP | 5.67280 |
Solubility | Almost insoluble in water, soluble in alcohol or fatty oil | Melting Point |
93-99oC |
Formula | C27H34O3 | Boiling Point | 546.9 °C at 760 mmHg |
Molecular Weight | 406.565 | Flash Point | 234.6 °C |
Transport Information | N/A | Appearance | White or milky crystalline powder |
Safety | 23-36 | Risk Codes | 20/21/22-40 |
Molecular Structure | Hazard Symbols | Xn | |
Synonyms |
17-beta-Hydroxy-estra-4-en-3-one, 17-phenylpropionate;17-beta-Phenylpropionyloxy-4-estren-3-one;3-Oxo-4-estren-17beta-yl-(3-phenylpropionat);Anticatabolin;Durabolin-50; |
Article Data | 17 |
Conditions | Yield |
---|---|
With bis(1-butyl-3-methylimidazolium) tungstate In 1,4-dioxane at 120℃; for 2.5h; | 74% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide In pyridine |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ammonium chloride; lithium / tetrahydrofuran; ethanol; ammonia; water 2: hydrogenchloride / methanol; water; benzene 3: hydrogenchloride; sodium hydroxide / pyridine View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / methanol; water; benzene 2: hydrogenchloride; sodium hydroxide / pyridine View Scheme |
activin
Conditions | Yield |
---|---|
Stage #1: activin With C19H26ClIrN3O(1+)*Cl(1-) In water; acetonitrile at 80℃; for 0.166667h; Green chemistry; Stage #2: With formic acid In water; acetonitrile at 80℃; for 4h; Green chemistry; | 25% |
The IUPAC name of Durabolin is [(8R,9S,10R,13S,14S,17S)-13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] 3-phenylpropanoate. With the CAS registry number 62-90-8, it is also named as Nandrolone phenpropionate. The classification codes are Anabolic Agents; Androgen; Hormone; Hormones, Hormone Substitutes, and Hormone Antagonists; Reproductive Effect. It is white or milky white crystalline powder with special smell. Additionally, Durabolin is almost insoluble in water, and soluble in alcohol or fatty oil. When heated to decomposition it emits acrid smoke and irritating vapors.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 5.97; (2)# of Rule of 5 Violations: 1; (3)#H bond acceptors: 3; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 5; (6)Index of Refraction: 1.577; (7)Molar Refractivity: 117.38 cm3; (8)Molar Volume: 354 cm3; (9)Polarizability: 46.53×10-24 cm3; (10)Surface Tension: 47.1 dyne/cm; (11)Enthalpy of Vaporization: 82.62 kJ/mol; (12)Vapour Pressure: 5.12E-12 mmHg at 25°C; (13)Rotatable Bond Count: 5; (14)Tautomer Count: 8; (15)Exact Mass: 406.250795; (16)MonoIsotopic Mass: 406.250795; (17)Topological Polar Surface Area: 43.4; (18)Heavy Atom Count: 30; (19)Complexity: 703.
Uses of Durabolin: It is used in dysplasia, nutritional disorders, consumption of the treatment of sexual disorders. And it also can used in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound healing, and endocrine function. In turn, Durabolin can inhibit follicle-stimulating hormone regulate follicle inhibit the synthesis and secretion.
People can use the following data to convert to the molecule structure.
1. SMILES:O=C5\C=C3/[C@@H]([C@H]2CC[C@@]4([C@@H](OC(=O)CCc1ccccc1)CC[C@H]4[C@@H]2CC3)C)CC5
2. InChI:InChI=1/C27H34O3/c1-27-16-15-22-21-11-9-20(28)17-19(21)8-10-23(22)24(27)12-13-25(27)30-26(29)14-7-18-5-3-2-4-6-18/h2-6,17,21-25H,7-16H2,1H3/t21-,22+,23+,24-,25-,27-/m0/s1.
The following are the toxicity data which has been tested.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. 6, Pg. 541, 1982. | |
rat | LD50 | intraperitoneal | 595mg/kg (595mg/kg) | Pharmaceutical Chemistry Journal Vol. 20, Pg. 143, 1986. |