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Name	Nylidrin hydrochloride	EINECS	212-701-0
CAS No.	849-55-8	Density	N/A
PSA	52.49000	LogP	4.61790
Solubility	N/A	Melting Point	198-199℃ (decomposition)
Formula	C₁₉H₂₅NO₂.ClH	Boiling Point	N/A
Molecular Weight	335.874	Flash Point	N/A
Transport Information	N/A	Appearance	N/A
Safety	36	Risk Codes	20/21/22
Molecular Structure		Hazard Symbols	Xn
Synonyms	Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-,hydrochloride (9CI);Benzyl alcohol, p-hydroxy-a-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-,hydrochloride (8CI);Nylidrin hydrochloride (6CI);Arlidin;Arlidinhydrochloride;Bufedon;Buphedrin;Buphenin hydrochloride;Bupheninehydrochloride;Dilatal;Dilatol;Dilatol hydrochloride;Dilatropon;Dilydrin;NSC 142004;Opino;Penitardon;Perdilatal;RHC 3432A;Rudilin;Rydrin;SKF 1700A;Suprifen Psb hydrochloride;Tocodilydrin;Tocodrin;Verina;p-Hydroxy-a-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzyl alcohol hydrochloride;	Article Data	2

Nylidrin hydrochloride Synthetic route

: C26H29NO2*ClH

: 849-55-8
nylidrin hydrochloride

Conditions

Conditions	Yield
With 3% Pd/C; hydrogen In methanol at 20℃;	95%

: 35081-45-9
1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone

: 22374-89-6
(RS)-1-methyl-3-phenylpropylamine

: 849-55-8
nylidrin hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / ethyl acetate / 5 h / Reflux 2: 3% Pd/C; hydrogen / methanol / 20 °C View Scheme

Nylidrin hydrochloride Chemical Properties

Product Name: Dilatol hydrochloride (CAS NO.849-55-8)

Molecular Formula: C₁₉H₂₆ClNO₂
Molecular Weight: 335.87g/mol
Mol File: 849-55-8.mol
Einecs: 212-701-0
Boiling point: 476 °C at 760 mmHg
Flash Point: 127.3 °C
Enthalpy of Vaporization: 77.91 kJ/mol
Vapour Pressure: 7.23E-10 mmHg at 25°C
H-Bond Donor: 4
H-Bond Acceptor: 3

Nylidrin hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	136mg/kg (136mg/kg)	Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973.
mouse	LD50	intravenous	40mg/kg (40mg/kg)	"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972.
mouse	LD50	oral	250mg/kg (250mg/kg)	"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972.
rat	LD50	intraperitoneal	380mg/kg (380mg/kg)	"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972.
rat	LD50	intravenous	37400ug/kg (37.4mg/kg)	United States Patent Document. Vol. #3542870,
rat	LD50	oral	> 4800mg/kg (4800mg/kg)	Drugs in Japan Vol. 6, Pg. 538, 1982.

Nylidrin hydrochloride Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits very toxic fumes of Cl− and NO_x.
Safety Information of Dilatol hydrochloride (CAS NO.849-55-8):
Hazard Codes: Xn
Risk Statements: 20/21/22
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing

Nylidrin hydrochloride Specification

Dilatol hydrochloride ,its CAS NO. is 849-55-8,the synonyms is 1-p-Hydroxyphenyl-2-(1'-methyl-3'-phenylpropylamino)-1-propanolhydrochloride ; Arlidinhydrochloride ; Bupheninehydrochloride ; Dilatolhydrochloride ; Dilatyl ; p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-benzylalcohohyd ; p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzylalcoholhydro ; Suprifenpsbhydrochloride .

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