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O-Methyl-L-threonine

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Name

O-Methyl-L-threonine

EINECS N/A
CAS No. 4144-02-9 Density 1.143 g/cm3
PSA 72.55000 LogP 0.13350
Solubility N/A Melting Point 214-216 °C
Formula C5H11NO3 Boiling Point 248 °C at 760 mmHg
Molecular Weight 133.147 Flash Point 103.8 °C
Transport Information N/A Appearance N/A
Safety 22-24/25 Risk Codes N/A
Molecular Structure Molecular Structure of 4144-02-9 (O-METHYL-L-THREONINE) Hazard Symbols N/A
Synonyms

Butyricacid, 2-amino-3-methoxy-, L- (8CI);(2S,3R)-2-Amino-3-methoxybutanoic acid;L-O-Methylthreonine;H-Thr(Me)-OH;O-Methylthreonine;

Article Data 9

O-Methyl-L-threonine Synthetic route

44975-87-3

N-formyl-O-methyl-Ls-threonine

4144-02-9

O-methyl-L-threonine

Conditions
ConditionsYield
With hydrogen bromide

(2S,3R)-2-Benzyloxycarbonylamino-3-methoxy-butyric acid; compound with dicyclohexyl-amine

4144-02-9

O-methyl-L-threonine

Conditions
ConditionsYield
(i) ion-exchange resin + form>, EtOH, H2O, (ii) H2, Pd-C; Multistep reaction;
70561-63-6

Benzyloxycarbonyl-O-methyl-threonin

4144-02-9

O-methyl-L-threonine

Conditions
ConditionsYield
With hydrogen; Pd-BaSO4
4144-14-3

methyl (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-methoxybutanoate

4144-02-9

O-methyl-L-threonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. LiOH / tetrahydrofuran
2: H2 / Pd/BaSO4
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid anhydride / 45 - 70 °C
2: brucine; ethanol
3: HBr
View Scheme
6622-23-7, 7153-82-4, 7505-36-4, 44975-87-3

N-formyl-O-methyl-DL-threonine

4144-02-9

O-methyl-L-threonine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: brucine; ethanol
2: HBr
View Scheme

N-Boc-L-Thr(Me)-OMe

4144-02-9

O-methyl-L-threonine

Conditions
ConditionsYield
With hydrogenchloride at 120℃; for 16h;
With hydrogenchloride In water at 110 - 120℃; for 16h;143 mg

perthamide C

A

107-97-1

sarcosine

B

4144-02-9

O-methyl-L-threonine

C

7423-92-9

o-hydroxyl-phenylalanine

D

6734-41-4

cis-4-methyl-(S)-proline

Conditions
ConditionsYield
With hydrogenchloride; water at 130℃;

perthamide C

A

4144-02-9

O-methyl-L-threonine

B

56-84-8

L-Aspartic acid

C

5753-30-0

erythro-β-hydroxy-D-aspartic acid

Conditions
ConditionsYield
With hydrogenchloride; water at 160℃;

perthamide D

A

4144-02-9

O-methyl-L-threonine

B

56-84-8

L-Aspartic acid

C

63-91-2

L-phenylalanine

D

5753-30-0

erythro-β-hydroxy-D-aspartic acid

Conditions
ConditionsYield
With hydrogenchloride; water at 160℃;

O-Methyl-L-threonine Specification

The L-Threonine, O-methyl-, with the CAS registry number 4144-02-9, is also known as (S)-2-Amino-3-methoxy-butyric acid. It belongs to the product categories of Threonine [Thr, T]; Amino Acids and Derivatives; Amino Acids and Derivatives. This chemical's molecular formula is C5H11NO3 and molecular weight is 133.15. Its systematic name is called O-methyl-L-threonine. When you are using this chemical, please be cautious about it. You should not breathe its dust. Besides, you must avoid contacting it with skin and eyes.

Physical properties of L-Threonine, O-methyl-: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 1; (4)ACD/KOC (pH 7.4): 1; (5)#H bond acceptors: 4; (6)#H bond donors: 3; (7)#Freely Rotating Bonds: 4; (8)Index of Refraction: 1.461; (9)Molar Refractivity: 31.97 cm3; (10)Molar Volume: 116.4 cm3; (11)Surface Tension: 41.8 dyne/cm; (12)Density: 1.143 g/cm3; (13)Flash Point: 103.8 °C; (14)Enthalpy of Vaporization: 53.42 kJ/mol; (15)Boiling Point: 248 °C at 760 mmHg; (16)Vapour Pressure: 0.008 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: OC(=O)[C@@H](N)C(C)OC
(2)InChI: InChI=1/C5H11NO3/c1-3(9-2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t3?,4-/m0/s1
(3)InChIKey: FYCWLJLGIAUCCL-BKLSDQPFBW

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