PHENYLMAGNESIUM BROMIDE Synthetic route
ConditionsConditions | Yield |
---|
With magnesium In tetrahydrofuran at 40℃; for 0.25h; Inert atmosphere; Flow reactor; | 100% |
With magnesium In tetrahydrofuran | |
With magnesium In diethyl ether at 19.9℃; Rate constant; various concentrations of aryl halide; | |
A
- 5606-39-3
(2-amino-5-chlorophenyl)-phenyl-methane-imine
A
1-phenyltetrafluoro-2-propenylacetate
ConditionsConditions | Yield |
---|
With magnesium In tetrahydrofuran | A 24% B n/a |
dichlorobis(triphenylphosphine)palladium[II]
Diisobutylaluminium hydride(1 M solution in tetrahydrofuran, 4.9 mL, 4.9 mmol)
ConditionsConditions | Yield |
---|
In tetrahydrofuran; toluene | |
- N-Z-(S)-serine methyl ester
N-Z-(S)-serine methyl ester
ConditionsConditions | Yield |
---|
With hydrogenchloride In diethyl ether | |
- (S)-Carbomethoxy oxazolidinone
(S)-Carbomethoxy oxazolidinone
- [NitriphosCl]PF6
[NitriphosCl]PF6
ConditionsConditions | Yield |
---|
With biphenyl; ethylmagnesium bromide; phenylmagnesium bromide In o-xylene | |
ConditionsConditions | Yield |
---|
With hydrogenchloride; iodine In magnesium | |
PHENYLMAGNESIUM BROMIDE Chemical Properties
Molecular Formula: C6H5BrMg
Molecular Weight: 181.31
EINECS: 202-867-2
Flash point: -11 ºC
Water solubility: reacts
Density: 1.134 g/mL at 25 °C
Storage temp: water-free area
Sensitive: Air & Moisture Sensitive
IUPAC Name: magnesium benzene bromide
Appearance: Clear light brown to brown solution when properly
Synonyms: Phenylmagnesium bromide ; Phenyl magnesium bromide(in ethyl ether) ; Bromophenyl-magnesiu ; Phenylmagnesiumbromidesolution ; Bromophenylmagnesium ; Phenylmagnesium bromide, 3.0m solution i n diethyl ether ; Phenylmagnesium bromide solution, ~1 m i n thf ; Phenylmagnesium bromide sol., ~3 m in di ethyl ether
Following is the molecular structure of Phenyl magnesium bromide (100-58-3):
PHENYLMAGNESIUM BROMIDE Production
Preparation of Phenyl magnesium bromide (100-58-3):
Phenylmagnesium bromide is commercially available as solutions of diethyl ether or THF. It may be prepared in the laboratory by treating bromobenzene with magnesium metal, usually in the form of ribbon. A small amount of iodine may be used to activate the magnesium to initiate the reaction.
Polar solvents, such as ether or THF, are required to solvate (complex) the magnesium(II) center. The solvent must be aprotic since alcohols and water react with phenylmagnesium bromide to give benzene. Carbonyl-containing solvents such as acetone and ethyl acetate are incompatible with the reagent.
PHENYLMAGNESIUM BROMIDE Safety Profile