The Phenylacetyl chloride with CAS registry number of 103-80-0 is also known as Phenylacetic acid chloride. The IUPAC name is 2-Phenylacetyl chloride. It belongs to product categories of Pharmaceutical Intermediates; Acid Halides; Carbonyl Compounds; Organic Building Blocks. Its EINECS registry number is 203-146-5. In addition, the formula is C₈H₇ClO and the molecular weight is 154.60. This chemical is a colourless liquid that soluble in water and ether. It may destroy living tissue on contact and should be sealed in ventilated, cool, dry place away from oxidants, alkali, alcohols and water. What's more, this chemical is used as intermediates for pharmaceuticals, pesticides, spices and organic synthesis.

Physical properties about Phenylacetyl chloride are: (1)ACD/LogP: 1.628; (2)ACD/LogD (pH 5.5): 1.63; (3)ACD/LogD (pH 7.4): 1.63; (4)ACD/BCF (pH 5.5): 10.17; (5)ACD/BCF (pH 7.4): 10.17; (6)ACD/KOC (pH 5.5): 183.07; (7)ACD/KOC (pH 7.4): 183.07; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.535; (11)Molar Refractivity: 40.681 cm³; (12)Molar Volume: 130.755 cm³; (13)Polarizability: 16.127 10-24cm³; (14)Surface Tension: 39.2970008850098 dyne/cm; (15)Density: 1.182 g/cm³; (16)Flash Point: 89.971 °C; (17)Enthalpy of Vaporization: 45.51 kJ/mol; (18)Boiling Point: 218.704 °C at 760 mmHg; (19)Vapour Pressure: 0.123999997973442 mmHg at 25°C

Preparation of Phenylacetyl chloride: it is prepared by reaction of benzeneacetic acid with thionyl chloride. The reaction releases sulfur dioxide and hydrogen chloride gas at room temperature. When reaction is complete, the reaction mixture is heated to 30-40 °C for 25 hours and benzene is added. After steaming volatile matter, product is obtained by collecting distillate at 55-57 °C (0.133kPa). The yield is about 80-85%.

Uses of Phenylacetyl chloride: it is used to produce 1,2-diphenyl-ethanone by reaction with iodobenzene. The reaction occurs with reagent NBu₄BF₄, catalyst NiBr₂bpy and solvent acetonitrile with ambient temperature. The yield is about 35%.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to respiratory system and reacts violently with water. It can cause burns. During using it, wear suitable protective clothing, gloves and eye/face protection. Avoid contact with eyes. After using it, take off immediately all contaminated clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If accident happens or you feel unwell seek medical advice immediately.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=CC=C(C=C1)CC(=O)Cl
2. InChI: InChI=1S/C8H7ClO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2
3. InChIKey: VMZCDNSFRSVYKQ-UHFFFAOYSA-N