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Name	Phenylindione	EINECS	N/A
CAS No.	83-12-5	Density	1.343g/cm³
PSA	34.14000	LogP	2.84940
Solubility	N/A	Melting Point	144-148 °C(lit.)
Formula	C15H10 O2	Boiling Point	243.3 °C (0.3 mmHg)
Molecular Weight	222.243	Flash Point	208
Transport Information	N/A	Appearance	light yellow fluffy fine flakes
Safety	A human poison by ingestion. Poison experimentally by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Human systemic effects by: blood effects, fever, hepatitis, hepatocellular necrosis, dermatitis, allergic effects, other skin effects, nausea or vomiting, tubule changes, urine volume decrease, interstitial nephritis. When heated to decomposition it emits acrid smoke and irritating fumes. Used to treat angina pectoris.	Risk Codes	25
Molecular Structure		Hazard Symbols
Synonyms	1,3-Indandione,2-phenyl- (6CI,8CI); 2-Phenyl-1,3-diketohydrindene; 2-Phenyl-1,3-indandione;2-Phenyl-1,3-indanedione; 2-Phenyl-1H-indene-1,3(2H)-dione; 2-Phenylindandione;Athrombon; Bindan; Cronodione; Danedion; Danilon; Danilone; Diadilan; Dindevan;Dineval; Diophindane; Emandion; Emandione; Fenhydren; Fenilin; Fenindion;Hedulin; Hemolidione; Indema; Indion; Indon; NSC 41693; PID; Phenhydren;Phenillin; Phenindione; Phenylen; Phenylin; Phenylindione; Pindione;Rectadione; Theradione; Thrombasal; Tromazal; Trombol	Article Data	68

Phenylindione Chemical Properties

IUPAC Name: 2-Phenylindene-1,3-dione
Synonyms:1H-Indene-1,3(2H)-dione, 2-phenyl- ; 2-Phenyl-1,3-indanedione ; 2-Phenyl-1H-indene-1,3(2H)-dione ; 2-Phenylindan-1,3-dione ; 2-Phenylindane-1,3-dione
Product Categories: Indane/Indanone and Derivatives
CAS NO:83-12-5
Molecular Formula of Phenylindione (CAS NO.83-12-5) :C₁₅H₁₀O₂
Molecular Weight of Phenylindione (CAS NO.83-12-5) :222.24
Molecular Structure of Phenylindione (CAS NO.83-12-5):
Index of Refraction: 1.637
Surface Tension: 53.2 dyne/cm
Density: 1.264 g/cm³
Flash Point: 153.4 °C
Enthalpy of Vaporization: 66.2 kJ/mol
Boiling Point: 409.8 °C at 760 mmHg
Vapour Pressure: 6.33E-07 mmHg at 25°C
Melting point: 144-148 °C(lit.)
Appearance:light yellow fluffy fine flakes

Phenylindione Uses

Phenylindione has actions similar to warfarin.

Phenylindione Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	LDLo	oral	48mg/kg/27D-I (48mg/kg)	BLOOD: OTHER CHANGES	New Zealand Medical Journal. Vol. 57, Pg. 283, 1958.
man	LDLo	unreported	1683mg/kg/31D (1683mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Lancet. Vol. 1, Pg. 920, 1963.
man	TDLo	oral	42500ug/kg/17 (42.5mg/kg)	KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	British Medical Journal. Vol. 1, Pg. 1655, 1963.
man	TDLo	unreported	22mg/kg/17D-I (22mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Annals of Internal Medicine. Vol. 52, Pg. 706, 1960.
man	TDLo	unreported	90mg/kg/27D-I (90mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	Canadian Medical Association Journal. Vol. 77, Pg. 1028, 1957.
mouse	LD50	intraperitoneal	150mg/kg (150mg/kg)		Pharmazie. Vol. 27, Pg. 520, 1972.
mouse	LD50	intravenous	130mg/kg (130mg/kg)	BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Therapie. Vol. 16, Pg. 34, 1961.
mouse	LD50	oral	175mg/kg (175mg/kg)		Schweizerische Medizinische Wochenschrift. Vol. 90, Pg. 213, 1960.
mouse	LD50	subcutaneous	140mg/kg (140mg/kg)		Dissertationes Pharmaceuticae. Vol. 8, Pg. 289, 1956.
rat	LD50	intraperitoneal	190mg/kg (190mg/kg)	BEHAVIORAL: REGIDITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Therapie. Vol. 16, Pg. 34, 1961.
rat	LD50	oral	163mg/kg (163mg/kg)		European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 519, 1974.

Phenylindione Safety Profile

A human poison by ingestion. Poison experimentally by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Human systemic effects by: blood effects, fever, hepatitis, hepatocellular necrosis, dermatitis, allergic effects, other skin effects, nausea or vomiting, tubule changes, urine volume decrease, interstitial nephritis. When heated to decomposition it emits acrid smoke and irritating fumes. Used to treat angina pectoris.
Hazard Codes Toxic T
Risk Statements 25
R25 :Toxic if swallowed.
Safety Statements 36/37/39-45
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS NK6125000
HazardClass 6.1(b)
PackingGroup III

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