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Cas Database |
| Name |
Piperacillin sodium salt |
EINECS | 261-868-6 |
| CAS No. | 59703-84-3 | Density | == |
| PSA | 184.56000 | LogP | -0.97950 |
| Solubility | Soluble in ethanol, water and methanol. | Melting Point |
183-185 °C (dec.) |
| Formula | C23H26N5NaO7S | Boiling Point | 707.1oC at 760 mmHg |
| Molecular Weight | 539.545 | Flash Point | 381.4oC |
| Transport Information | N/A | Appearance | White to off-white crystalline powder |
| Safety | 22-36/37-45 | Risk Codes | 42/43 |
| Molecular Structure |
|
Hazard Symbols |
 Xn
|
| Synonyms |
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[(2R)-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, [2S-[2a,5a,6b(S*)]]-;Piperacillin sodium;Piperacillin-Na;Sodium piperacillin; |
Article Data | 3 |
Piperacillin sodium salt Chemical Properties
Structure of Piperacillin sodium salt (CAS NO.59703-84-3):
Molecular Formula: C23H26N5NaO7S
Molar mass: 539.54 g/mol
EINECS: 261-868-6
H bond acceptors: 12
H bond donors: 3
Freely Rotating Bonds: 6
Polar Surface Area: 166.98Å2
Melting point: 183-185 C (dec.)
Storage temp: Store at 0-5°C
Appearance: White to off-white crystalline powder
Solubility: H2O: 50 mg/mL
Product Categories: beta-Lactams; Antibiotics N-SAntibiotics; Chemical Structure Class; L - ZAntibiotics; Mechanism of Action; Antibiotic Explorer; Biochemistry
InChI
InChI=1/C23H27N5O7S.Na/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28;/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34);/q;+1/p-1/t13-,14+,15-,20+;/m1./s1
Smiles
N12[C@H]([C@H](NC([C@@H](c3ccccc3)NC(N3C(C(N(CC)CC3)=O)=O)=O)=O)C2=O)SC(C)(C)[C@H]1C(=O)[O-].[Na+]
Piperacillin sodium salt Toxicity Data With Reference
| dog | LD50 | intravenous | > 6gm/kg (6000mg/kg) | Japanese Journal of Antibiotics. Vol. 36, Pg. 653, 1983. | |
| monkey | LD50 | intravenous | > 4gm/kg (4000mg/kg) | Drugs in Japan Vol. 6, Pg. 634, 1982. | |
| mouse | LD50 | intraperitoneal | 9770mg/kg (9770mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Chemotherapy Vol. 25, Pg. 816, 1977. |
| mouse | LD50 | intravenous | 4900mg/kg (4900mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Chemotherapy Vol. 25, Pg. 816, 1977. |
| mouse | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. 634, 1982. | |
| mouse | LD50 | subcutaneous | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. 634, 1982. | |
| rat | LD50 | intraperitoneal | 7600mg/kg (7600mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Chemotherapy Vol. 25, Pg. 816, 1977. |
| rat | LD50 | intravenous | 2260mg/kg (2260mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 884, 1979. | |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. 634, 1982. | |
| rat | LD50 | subcutaneous | 8800mg/kg (8800mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 884, 1979. | |
| rat | LD50 | unreported | 2gm/kg (2000mg/kg) | United States Patent Document. Vol. #4535078, | |
| women | TDLo | intramuscular | 960mg/kg/3D-I (960mg/kg) | BLOOD: HEMORRHAGE | Southern Medical Journal. Vol. 78, Pg. 363, 1985. |
| women | TDLo | intravenous | 2180mg/kg/6D- (2180mg/kg) | BLOOD: NORMOCYTIC ANEMIA BLOOD: LEUKOPENIA | Southern Medical Journal. Vol. 79, Pg. 255, 1986. |
Piperacillin sodium salt Safety Profile
Moderately toxic by intravenous route. An experimental teratogen. Human systemic effects: normocytic anemia, leukopenia, hemorrhage. When heated to decomposition it emits toxic fumes of SOx, NOx and Na2O.
Hazard Codes: Xn
Risk Statements: 42/43
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 22-36/37-45
S22:Do not breathe dust.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 2
RTECS: XI0180000
Piperacillin sodium salt Specification
3-Methyl-1-(4-sulfophenyl)-2-pyrazolin-5-one , with CAS number of 59703-84-3, can be called 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, [2S-[2a,5a,6b(S*)]]- ; Piperacillin-Na ; PiperacillinSodium/TazobactamSodium . Piperacillin sodium salt (CAS NO.59703-84-3) is the semi-synthetic antibiotics with broad-spectrum antibacterial activity and have good antibacterial activity against Gram-positive and-negative bacteria.
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