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Pirenzepine

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Name

Pirenzepine

EINECS 249-228-4
CAS No. 28797-61-7 Density N/A
PSA 74.23000 LogP 2.80740
Solubility

Stability

Toxicology

    No toxicological data available.

    Toxicity data
    (The meaning of any toxicological abbreviations which appear in this section is given

Melting Point 226 - 230 C
Formula C19H21 N5 O2 Boiling Point 541.7°C at 760 mmHg
Molecular Weight 351.408 Flash Point 281.4°C
Transport Information N/A Appearance solid
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 28797-61-7 (Pirenzepine) Hazard Symbols N/A
Synonyms

6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one,5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]- (8CI,9CI); Pirenzepin;Pirenzepine

Article Data 5

Pirenzepine Chemical Properties

Molecular structure of Pirenzepine (CAS NO.28797-61-7) is:

Product Name: Pirenzepine
CAS Registry Number: 28797-61-7
IUPAC Name: 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Molecular Weight: 351.40234 [g/mol]
Molecular Formula: C19H21N5O2
XLogP3: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 5 
Surface Tension: 53.7 dyne/cm
Density: 1.271 g/cm3
Flash Point: 281.4 °C
Enthalpy of Vaporization: 81.97 kJ/mol
Boiling Point: 541.7 °C at 760 mmHg
Vapour Pressure: 8.44E-12 mmHg at 25°C
Classification Code: Anti-ulcer agents ;Cholinergic Agents ;Cholinergic Antagonists ;Drug / Therapeutic Agent ;Gastrointestinal Agents ;Muscarinic antagonists ;Neurotransmitter Agents 
Product Categories: Muscarinic

Pirenzepine Uses

 Pirenzepine (CAS NO.28797-61-7) is an antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as Cimetidine and Ranitidine. It is generally well tolerated by patients. Aslo, it can used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It has no effects on the brain and spinal cord as it cannot diffuse through the blood-brain barrier. And it has been investigated for use in myopia control.

Pirenzepine Toxicity Data With Reference

 

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 427mg/kg (427mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 245, 1991.
mouse LD50 intravenous 156mg/kg (156mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 245, 1991.
mouse LD50 oral 3046mg/kg (3046mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 245, 1991.
rat LD50 oral > 5gm/kg (5000mg/kg)   Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 26, Pg. 245, 1991.

Pirenzepine Specification

 Pirenzepine , its cas register number is 28797-61-7. It also can be called Pirenzepine [INN:BAN] ; 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one ; 5,11-Dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one ; BRN 0628987 ; EINECS 249-228-4 ; Pirenzepin ; Pirenzepina ; Pirenzepina [INN-Spanish] ; Pirenzepinum ; Pirenzepinum [INN-Latin] ; UNII-3G0285N20N ; 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)- .And, it is a solid.

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