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Poly(ethylene oxide)
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Name

Poly(ethylene oxide)

 EINECS 203-473-3
CAS No. 25322-68-3 Density 1.27 g/mL at 25 °C
PSA 40.46000 LogP -1.02900
Solubility Water soluble Melting Point 64-66 °C
Formula C2nH4n+2On+1 Boiling Point >250 °C
Molecular Weight N/A Flash Point 270 °C
Transport Information N/A Appearance White waxy crystalline flakes
Safety 26-36-24/25 Risk Codes 36/38
Molecular Structure Molecular Structure of 25322-68-3 (Poly(ethylene glycol)) Hazard Symbols IrritantXi
Synonyms

Glycols, polyethylene;Glycols,polyethylene (8CI);AlkoxE 130;Alkox E 30;Alkox E 30G;Alkox R 100;Alkox R 15;Alkox R 400;Alkox SW;AquaCalk TWB-P;Aquaffin;Badimol;Breox 20M;Breox PEG 300;CBP 20;Carbowax 14000;Carbowax 1450;Carbowax 1500;Carbowax 4500;Carbowax E 300;CarbowaxSentry NF;Cartaretin E;Cerasol 250A;Chemiox E20(C);Gligogum 4000;H 22;HM 500;HPEO 4250;IW;KPEG 6000;KleanPrep;L 6;Laprol 1001;Polyethylene glycol;

Article Data 9

Poly(ethylene oxide) Specification

The Poly(ethylene oxide), with the CAS registry number 25322-68-3, is also known as 1,2-Ethanediol homopolymer. It belongs to the product categories of Polymers; Optimization Reagents; Protein Structural Analysis; X-Ray Crystallography; Cosmetic Ingredients & Chemicals; Gas Chromatography; Packed GC; Stationary Phases; Homobifunctional PEG; Poly(ethylene glycol) (PEG) and PEG Solutions; Poly(ethylene glycol) and Oligo(ethylene glycol); Essential Chemicals; Inorganic Salts; Materials Science; Poly(ethylene glycol) and Poly(ethylene oxide); Research Essentials; Solutions and Reagents. This chemical's molecular formula is C2nH4n+2On+1.  This chemical is a polyether compound with many applications from industrial manufacturing to medicine.

Physical properties about Poly(ethylene oxide) are: (1)ACD/LogP: 0.046; (2)ACD/LogD (pH 5.5): -2.42; (3)ACD/LogD (pH 7.4): -2.48; (4)ACD/BCF (pH 5.5): 1.00 ; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 4; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 8; (11)Index of Refraction: 1.477; (12)Molar Refractivity: 48.833 cm3; (13)Molar Volume: 172.896 cm3; (14)Polarizability: 19.359 10-24cm3; (15)Surface Tension: 43.2919998168945 dyne/cm; (16)Density: 1.083 g/cm3; (17)Flash Point: 169.77 °C; (18)Enthalpy of Vaporization: 66.181 kJ/mol; (19)Boiling Point: 357.104 °C at 760 mmHg

Preparation of Poly(ethylene oxide): Poly(ethylene oxide) is produced by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers.[5] The reaction is catalyzed by acidic or basic catalysts. Ethylene glycol and its oligomers are preferable as a starting material instead of water, because they allow the creation of polymers with a low polydispersity (narrow molecular weight distribution). Polymer chain length depends on the ratio of reactants.

HOCH2CH2OH + n(CH2CH2O) → HO(CH2CH2O)n+1H

Uses of Poly(ethylene oxide): It is used as an excipient in many pharmaceutical products. Moreocer, it is used in conjunction with carbon black to form a conductive composite. This product should be sealed and stored in a cool, ventilated and dry place. Moreover, it is heat-stable and inert to many chemical agents and will not hydrolyze or deteriorate under normal conditions.

When you are using this chemical, please be cautious about it as the following: This chemical is irritating to eyes and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing and you must avoid contact with skin and eyes.

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 3gm/kg (3000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
guinea pig LD50 oral 15700mg/kg (15700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 17gm/kg (17000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
guinea pig LD50 oral 19600mg/kg (19600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 22500mg/kg (22500mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
guinea pig LD50 oral 28gm/kg (28000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
guinea pig LD50 oral 28900mg/kg (28900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 50gm/kg (50000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
guinea pig LD50 oral 50900mg/kg (50900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
mouse LD50 intraperitoneal 473mg/kg (473mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 21, Pg. 387, 1986.
mouse LD50 intraperitoneal 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
mouse LD50 intraperitoneal 7500mg/kg (7500mg/kg)   National Technical Information Service. Vol. AD628-313,
mouse LD50 intraperitoneal 8gm/kg (8000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 293, 1951.
mouse LD50 intravenous 7900ug/kg (7.9mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 316, 1970.
mouse LD50 intravenous 8550mg/kg (8550mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 intravenous 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
mouse LD50 oral 28915mg/kg (28915mg/kg)   Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976.
mouse LD50 oral 31gm/kg (31000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 oral 34gm/kg (34000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 oral 36gm/kg (36000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
mouse LD50 subcutaneous 18gm/kg (18000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD skin > 1gm/kg (1000mg/kg)   Union Carbide Data Sheet. Vol. 9/25/1969,
rabbit LD50 intravenous 8gm/kg (8000mg/kg) BLOOD: CHANGE IN CLOTTING FACTORS Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 4, Pg. 71, 1978.
rabbit LD50 oral 14gm/kg (14000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rabbit LD50 oral 17300mg/kg (17300mg/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 oral 17300mg/kg (17300mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 19gm/kg (19000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rabbit LD50 oral 26800mg/kg (26800mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 28900mg/kg (28900mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 oral 76gm/kg (76000mg/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 oral 76gm/kg (76000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rabbit LD50 skin > 20mL/kg (20mL/kg)   International Journal of Toxicology. Vol. 18(Suppl,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1112,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2202,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-96,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2203,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-937,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-939,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-935,
rabbit LD50 skin > 20gm/kg (20000mg/kg)   Dow Chemical Company Reports. Vol. MSD-940,
rat LD oral > 4gm/kg (4000mg/kg)   Union Carbide Data Sheet. Vol. 9/25/1969,
rat LD50 intraperitoneal 6790mg/kg (6790mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 9gm/kg (9000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 9700mg/kg (9700mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intraperitoneal 9708mg/kg (9708mg/kg)   Proceedings of the European Society of Toxicology. Vol. 17, Pg. 351, 1976.
rat LD50 intraperitoneal 12600mg/kg (12600mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 14100mg/kg (14100mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intraperitoneal 15390mg/kg (15390mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 15570mg/kg (15570mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intraperitoneal 17gm/kg (17000mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
rat LD50 intraperitoneal 17700mg/kg (17700mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 intravenous 7130mg/kg (7130mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intravenous 7312mg/kg (7312mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 intravenous 7500mg/kg (7500mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3849, 1982.
rat LD50 intravenous 13gm/kg (13000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 600mg/kg (600mg/kg)   Dow Chemical Company Reports. Vol. MSD-94,
rat LD50 oral 1054mg/kg (1054mg/kg)   Dow Chemical Company Reports. Vol. MSD-95,
rat LD50 oral > 4gm/kg (4000mg/kg)   Dow Chemical Company Reports. Vol. MSD-938,
rat LD50 oral 22gm/kg (22000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral 27500mg/kg (27500mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 28gm/kg (28000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1112,
rat LD50 oral 30gm/kg (30000mg/kg)   Dow Chemical Company Reports. Vol. MSD-2203,
rat LD50 oral 30200mg/kg (30200mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 349, 1950.
rat LD50 oral 31600mg/kg (31600mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral 31640mg/kg (31640mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 32gm/kg (32000mg/kg)   Dow Chemical Company Reports. Vol. MSD-937,
rat LD50 oral 44200mg/kg (44200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 45gm/kg (45000mg/kg)   "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3847, 1982.
rat LD50 oral 50gm/kg (50000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral > 50gm/kg (50000mg/kg)   Dow Chemical Company Reports. Vol. MSD-935,
rat LD50 oral 50gm/kg (50000mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 747, 1969.
rat LD50 oral > 50gm/kg (50000mg/kg)   Dow Chemical Company Reports. Vol. MSD-940,
rat LD50 oral 50gm/kg (50000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 51200mg/kg (51200mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 oral 51310mg/kg (51310mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 subcutaneous 16gm/kg (16000mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 451, 1953.
rat LD50 unreported 7800mg/kg (7800mg/kg)   United States Patent Document. Vol. #4767763,
rat LDLo intravenous 3mg/kg (3mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 442, 1970.
rat LDLo intravenous 22gm/kg (22000mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

KIDNEY, URETER, AND BLADDER: HEMATURIA		 Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1087, 1973.

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