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Procarbazine hydrochloride
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Name

Procarbazine hydrochloride

 EINECS 206-678-6
CAS No. 366-70-1 Density 8.3 g/cm3
PSA 53.16000 LogP 3.02350
Solubility >=10 g/100 mL at 21.5 °C Melting Point 223 °C
Formula C12H19N3O.HCl Boiling Point 384.6 °C at 760 mmHg
Molecular Weight 257.763 Flash Point 148.9 °C
Transport Information N/A Appearance white to pale yellow crystalline powder
Safety 53-36/37-45 Risk Codes 45-61-22-68
Molecular Structure Molecular Structure of 366-70-1 (Procarbazine hydrochloride) Hazard Symbols T
Synonyms

Benzamide,N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride (9CI);p-Toluamide, N-isopropyl-a-(2-methylhydrazino)-, monohydrochloride (8CI);1-Methyl-2-[p-(isopropylcarbamoyl)benzyl]hydrazine hydrochloride;2-[p-(Isopropylcarbamoyl)benzyl]-1-methylhydrazine hydrochloride;IBZ;Ibenzmethyzin hydrochloride;Ibenzmethyzine hydrochloride;MBH;MIHhydrochloride;Matulane;N-Isopropyl-p-(2-methylhydrazinomethyl)benzamidehydrochloride;N-Isopropyl-a-(2-methylhydrazino)-p-toluamide hydrochloride;NCI-C 01810;NSC 77213;Nathulane;Natulan;Natulan hydrochloride;Natulanar;PCB hydrochloride;Ro 4 6467/1;Ro 4-6467;Benzamide,N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-, hydrochloride (1:1);

Article Data 2

Procarbazine hydrochloride Chemical Properties

The Molecular formula of Procarbazine hydrochloride (CAS NO.366-70-1): C12H20ClN3O  
The Molecular Weight of Procarbazine hydrochloride (CAS NO.366-70-1): 257.76
The Molecular Structure of Procarbazine hydrochloride (CAS NO.366-70-1):

Melting point: 223°C
Boiling point: 384.6 °C at 760 mmHg
Flash point: 148.9 °C    
Solubility in water: >=10 g/100 mL at 21.5 °C     
Air & Water Reactions: In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen.  
Enthalpy of Vaporization: 63.33 kJ/mol 
Vapour Pressure: 4.05E-06 mmHg at 25°C
Appearance: white to pale yellow crystalline powder with a slight odor. Acid to litmus.
IUPAC Name: 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide hydrochloride  

Procarbazine hydrochloride Toxicity Data With Reference

1.    

dnd-rat-ipr 25 mg/kg

     ENMUDM    Environmental Mutagenesis. 7 (1985),563.
2.    

hma-mus/esc 100 mg/kg

     MUREAV    Mutation Research. 164 (1986),19.
3.    

ivn-rat TDLo:125 mg/kg (22D preg):ETA,REP

     ARZNAD    Arzneimittel-Forschung. Drug Research. 22 (1972),905.
4.    

orl-rat LD50:570 mg/kg

     OYYAA2    Oyo Yakuri. Pharmacometrics. 6 (1972),355.
5.    

scu-rat LD50:490 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),720.
6.    

ivn-rat LD50:350 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 20 (1970),1467.
7.    

orl-rat LD50:785 mg/kg

     EVSRBT    Environmental Science Research. 24 (1981),977.
8.    

orl-mus LD50:560 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 4 (1973),467.
9.    

ipr-mus LD50:699 mg/kg

     ARTODN    Archives of Toxicology. 41 (1979),287.
10.    

scu-mus LD50:710 mg/kg

     IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 4 (1973),467.

Procarbazine hydrochloride Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2A IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 327.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 311.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 311.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (ipr); Clear Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-19 ,1979. ; (ipr); Clear Evidence: mouse, rat RRCRBU    Recent Results in Cancer Research. 52 (1975),1. . EPA Genetic Toxicology Program.

Procarbazine hydrochloride Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.

Procarbazine hydrochloride Specification

 Procarbazine hydrochloride (CAS NO.366-70-1) can also be called as N-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride ; Procarbazine hcl ; Procarbazine hydrochloride ; Chlorhydratede1-methyl2p(isopropylcarbamoyl)benzyl-hydrazine ; 1-(P-isopropylcarbamoylbenzyl)-2-methylhydrazinehydrochloride ; 1-Methyl-2-(p-isopropylcarbamoylbenzyl)hydrazinehydrochloride ; 1-Methyl-2-p-(isopropylcarbamyol)benzohydrazinehydrochloride ; 2-(P-(isopropylcarbamoyl)benzyl)-1-methylhydrazinehydrochloride .

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