3-Aminophenol

Base Information Edit

Chemical Name:3-Aminophenol
CAS No.:591-27-5
Molecular Formula:C6H7NO
Molecular Weight:109.128
Hs Code.:29222900
European Community (EC) Number:209-711-2
NSC Number:1546
UN Number:2512
UNII:L3WTS6QT82
DSSTox Substance ID:DTXSID3024497
Nikkaji Number:J1.644F
Wikipedia:3-Aminophenol
Wikidata:Q779427
Metabolomics Workbench ID:51892
ChEMBL ID:CHEMBL269755
Mol file:591-27-5.mol

Synonyms:Phenol,m-amino- (8CI);(3-Hydroxyphenyl)amine;1-Amino-3-hydroxybenzene;3-Hydroxybenzenamine;C.I. OxidationBase 7;Fourrine 65;Fourrine EG;Nako TEG;m-Hydroxyphenylamine;

Suppliers and Price of 3-Aminophenol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Amino-3-Hydroxybenzene
100g
$ 185.00

TRC
1-Amino-3-Hydroxybenzene
10g
$ 135.00

TCI Chemical
3-Aminophenol >98.5%(GC)(T)
500g
$ 142.00

TCI Chemical
3-Aminophenol >98.5%(GC)(T)
25g
$ 23.00

SynQuest Laboratories
3-Aminophenol
100 g
$ 26.00

SynQuest Laboratories
3-Aminophenol
500 g
$ 64.00

SynQuest Laboratories
3-Aminophenol
1 kg
$ 112.00

Sigma-Aldrich
3-Aminophenol United States Pharmacopeia (USP) Reference Standard
300mg
$ 1160.00

Sigma-Aldrich
3-Aminophenol for synthesis
50 kg
$ 3848.00

Sigma-Aldrich
3-Aminophenol for synthesis
1 kg
$ 183.15

Total 162 raw suppliers

Chemical Property of 3-Aminophenol Edit

Chemical Property:

Appearance/Colour:White crystals or off-white flakes
Vapor Pressure:0.019Pa at 20℃
Melting Point:121 °C
Refractive Index:1.5444 (estimate)
Boiling Point:298.566 °C at 760 mmHg
PKA:4.37, 9.82(at 20℃)
Flash Point:116.4±19.8 °C
PSA：46.25000
Density:1.2±0.1 g/cm³
LogP:1.55560
Storage Temp.:2-8°C
Solubility.:26g/l
Water Solubility.:35 g/L (20 ºC)
XLogP3:0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:109.052763847
Heavy Atom Count:8
Complexity:74.9
Transport DOT Label:Poison

Purity/Quality:

99.0% ^*data from raw suppliers

1-Amino-3-Hydroxybenzene ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,N
Hazard Codes:Xn,N
Statements: 20/22-51/53
Safety Statements: 28-61-28A

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Nitrogen Compounds -> Amino Phenols
Canonical SMILES:C1=CC(=CC(=C1)O)N
Uses m-Aminophenol (MAP) is an important starting material for dyes, including a variety of leuco (or latent) dyes used in imaging technology, optical bleaches and fluorescent agents, drugs, agricultural chemicals; and high-performance polymers. Although the synthesis of m-aminophenol(s) by the reaction of resorcinol with ammonia or (di)alkylarnines has been known for about 100 years,the preferred manufacturing process had been for many years a route involving the sulfonation of nitrobenzene to m-nitrobenzenesulfonic acid, the reduction of the nitro group to give m-aminobenzenesulfonic acid, followed by the caustic fusion of sodium m-aminobenzenesulfonate to yield sodium m-aminophenolate. The m-aminophenol was isolated/purified by neutralization, filtration, and recrystallization; the overall yield of m-aminophenol from nitrobenzene was estimated by SRI International to be 58%. (Doubtless, process improvements were made by the producers using this process.) The nitrobenzene/sulfonationlreductionlcaustic fusion route is still being used commercially, notably by ACNA in Italy, the largest producer of MAP, as well as a few smaller manufacturers. Sumitomo Chemical Co. used this process as well into the early 1980s and had licensed their knowhow to Hindustani Organic Chemicals, Ltd. of India which started up a plant on this basis with a capacity for MAP of 1.5 mill. lb /yr in 1970.The output of the Indian plant was said to be devoted to making sodium p-aminosalycilate (PAS), a tuberculostatic agent. 3-Aminophenol is an aromatic compound used in the preparation of inhibitors of mammalian carbonic anhydrase isoforms. Also used in the preparation of quinoline tethered fluorescent carbon dots for regulated anticancer discovery. Dye intermediate, manufacture of p-aminosalicylic acid.

Technology Process of 3-Aminophenol

There total 84 articles about 3-Aminophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%