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Technology Process of Phosphatidylserine

Phosphatidylserine

Base Information Edit
  • Chemical Name:Phosphatidylserine
  • CAS No.:51446-62-9
  • Molecular Formula:C42H82NO10P
  • Molecular Weight:792.088
  • Hs Code.:2922491990
  • UNII:394XK0IH40
  • DSSTox Substance ID:DTXSID10866199
  • Nikkaji Number:J1.757.189C
  • Wikidata:Q27157825
  • NCI Thesaurus Code:C68417
  • Metabolomics Workbench ID:16438
  • ChEMBL ID:CHEMBL4297669
  • Mol file:51446-62-9.mol
Phosphatidylserine

Synonyms:Phosphatidyl Serine;Phosphatidyl Serines;Phosphatidylserine;Phosphatidylserines;Phosphoglycerides, Serine;Serine Phosphoglycerides;Serine, Phosphatidyl;Serines, Phosphatidyl

Suppliers and Price of Phosphatidylserine
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Matrix Scientific
  • (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoic acid 95+%
  • 250mg
  • $ 1040.00
  • Arctom
  • (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoicacid ≥98%
  • 25g
  • $ 135.00
  • Arctom
  • (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoicacid ≥98%
  • 5g
  • $ 37.00
  • Arctom
  • (2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoicacid ≥98%
  • 1g
  • $ 10.00
  • American Custom Chemicals Corporation
  • PHOSPHATIDYLSERINE 95.00%
  • 100MG
  • $ 1335.51
  • American Custom Chemicals Corporation
  • PHOSPHATIDYLSERINE 95.00%
  • 5MG
  • $ 591.45
Total 160 raw suppliers
Chemical Property of Phosphatidylserine Edit
Chemical Property:
  • Appearance/Colour:White or light yellow loose powder 
  • Vapor Pressure:5.04E-14mmHg at 25°C 
  • Refractive Index:1.495 
  • Boiling Point:560.299 °C at 760 mmHg 
  • PKA:1.31±0.50(Predicted) 
  • Flash Point:292.658 °C 
  • PSA：181.49000 
  • Density:1.359 g/cm3 
  • LogP:12.21020 
  • Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C 
  • XLogP3:12.1
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:11
  • Rotatable Bond Count:44
  • Exact Mass:791.56763481
  • Heavy Atom Count:54
  • Complexity:937
Purity/Quality:

50%, *data from raw suppliers

(2S)-2-Amino-3-((((R)-2,3-bis(stearoyloxy)propoxy)-(hydroxy)phosphoryl)oxy)propanoic acid 95+% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Chemical Classes:Lipids -> Unambiguous Lipids
  • Canonical SMILES:CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC
  • Isomeric SMILES:CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OC[C@@H](C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCCC
  • Recent ClinicalTrials:ADAM17 and Vascular Function in Diabetes
  • Description Phosphatidylserine (PS) is quite literally a “brain nutrient.” As a matter of fact, this phospholipid is an integral component in the structure of the brain and spinal cord, and is active at cell membranes (including synaptic membrane zones).It plays a key role in cell cycle signaling, specifically in relationship to apoptosis. Studies have provided evidence that PS may promote attention, memory, processing speed, and support overall cognitive health. PS may also support healthy stress and cortisol levels. A significant amount of published clinical research has demonstrated that PS supplementation supports various cognitive parameters in children, including those with ADHD.
  • Uses Phosphatidylserine is a brain-boosting supplement. It is a class of phospholipids found in cell membranes. Its levels and location within the brain can affect important signaling pathways for cell survival and communication. Phosphatidylserine includes two fatty acids that can vary from saturated or monounsaturated to polyunsaturated omega-6 and omega-3 versions like docosahexaenoic acid (DHA). Some clinical trials of phosphatidylserine supplements have shown modestly improved cognitive function, but better designed trials reported no benefit.
  • Biological Functions Phosphatidylserine (PS) is a glycerophospholipid consisting of a phosphatidyl group attached to L-serine via a phosphodiester linkage. PS is a critical component of the cellular plasma membrane and accounts for 2-15% of plasma membrane lipid composition, depending on the cell or tissue type. The highest concentrations of PS are found in neuronal tissues, which are critical for maintaining conduction velocity in myelinated neurons, as well as for higher order cognitive skills such as learning and memory. In normal, healthy cells, PS is held in the inner membrane surface (facing the cytosol) by the lipid transporter protein flippase. However, in apoptotic cells, PS molecules ‘shuffle’ between the inner and outer plasma membrane monolayers. When PS molecules flip to the extracellular (outer) surface of the cell membrane, they act as a signal for macrophages to engulf and digest the (apoptotic) cell.
Technology Process of Phosphatidylserine

There total 5 articles about Phosphatidylserine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,2-distearoyl-sn-glycerol-3-phosphoryl-N-Troc-serine

1,2-distearoyl-sn-glycerol-3-phosphoryl-N-Troc-serine

1,2-distearoyl-sn-glycero-3-phosphatidylserine
51446-62-9

1,2-distearoyl-sn-glycero-3-phosphatidylserine

Guidance literature:
With acetic acid; zinc; at 25 ℃; for 10h;

Reference yield:

1,2-distearoyl-sn-glycero-3-phosphoryl-N-Troc-serine benzyl ester

1,2-distearoyl-sn-glycero-3-phosphoryl-N-Troc-serine benzyl ester

1,2-distearoyl-sn-glycero-3-phosphatidylserine
51446-62-9

1,2-distearoyl-sn-glycero-3-phosphatidylserine

Guidance literature:
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 5 h / 20 °C
2: acetic acid; zinc / 10 h / 25 °C
With palladium 10% on activated carbon; hydrogen; acetic acid; zinc; In tetrahydrofuran;

Reference yield:

1,2-O-isopropylideneglycerol-3-phosphoryl-N-Troc-serine benzyl ester

1,2-O-isopropylideneglycerol-3-phosphoryl-N-Troc-serine benzyl ester

1,2-distearoyl-sn-glycero-3-phosphatidylserine
51446-62-9

1,2-distearoyl-sn-glycero-3-phosphatidylserine

Guidance literature:
Multi-step reaction with 4 steps
1: hydrogenchloride / water; methanol / 5 h / 20 °C
2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 2 h / 5 °C
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 5 h / 20 °C
4: acetic acid; zinc / 10 h / 25 °C
With hydrogenchloride; dmap; palladium 10% on activated carbon; hydrogen; acetic acid; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; dichloromethane; water;
upstream raw materials:

N-benzyloxycarbonyl-O-[((R)-2,3-bis-stearoyloxy-propoxy)-phenoxy-phosphoryl]-L-serine benzyl ester

Refernces Edit

Total 8 Pictures about this product

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