Diethyl 2-chlorobenzylphosphonate

Base Information

• Chemical Name: Diethyl 2-chlorobenzylphosphonate
• CAS No.: 29074-98-4
• Molecular Formula: C11H16ClO3P
• Molecular Weight: 262.673
• Mol file: 29074-98-4.mol

Synonyms:2-chlorobenzyl diethylphosphonate;

Chemical Property of Diethyl 2-chlorobenzylphosphonate

Chemical Property:

• Refractive Index: 1.5060 to 1.5140
• Boiling Point: 146°C/0.4mmHg(lit.)
• PSA: 45.34000
• LogP: 4.10610
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Diethyl (2-Chlorobenzyl)phosphonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diethyl 2-chlorobenzylphosphonate

There total 5 articles about Diethyl 2-chlorobenzylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-bromomethyl-2-chlorobenzene (611-17-6) + triethyl phosphite (122-52-1) → 2-chlorobenzyl diethylphosphonate (29074-98-4)

Guidance literature:

at 150 ℃; Inert atmosphere; neat (no solvent);

DOI:10.1021/ma1024494

Reference yield: 88.0%

1-chloro-2-(chloromethyl)benzene (611-19-8) + triethyl phosphite (122-52-1) → 2-chlorobenzyl diethylphosphonate (29074-98-4)

Guidance literature:

Reference yield: 80.0%

2-Chlorobenzyl alcohol (17849-38-6) + triethyl phosphite (122-52-1) → 2-chlorobenzyl diethylphosphonate (29074-98-4)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; at 120 ℃; for 24h; Inert atmosphere;

upstream raw materials:

1-chloro-2-(chloromethyl)benzene

triethyl phosphite

1-bromomethyl-2-chlorobenzene

2-Chlorobenzyl alcohol

Downstream raw materials:

(E)-1-chloro-2-(hept-1-en-6-yn-1-yl)benzene

trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine maleate

asenapine

trans-2,5'-dichloro-2'-hydroxystilbene

Refernces

• 1、 Ma, Xiantao,Xu, Qing,Li, Huan,Su, Chenliang,Yu, Lei,Zhang, Xu,Cao, Hongen,Han, Li-Biao. "Alcohol-based Michaelis-Arbuzov reaction: An efficient and environmentally-benign method for C-P(O) bond formation". supporting information. p. 3408 - 3413. Retrieved 2018/08/06.
• 2、 -. "PROCESS FOR THE PREPARATION OF TETRACYCLIC DERIVATIVES AND INTERMEDIATE PRODUCTS USED IN THE PROCESS". Page/Page column 16-17. . Retrieved 2012/04/17.