3-(5-Bromo-thiophen-2-yl)-acrylic Acid

Base Information

Chemical Name:3-(5-Bromo-thiophen-2-yl)-acrylic Acid
CAS No.:29079-97-8
Molecular Formula:C7H5BrO2S
Molecular Weight:233.085
Hs Code.:
DSSTox Substance ID:DTXSID601284053
Mol file:29079-97-8.mol

Synonyms:UNAWXLDSXIIUFC-UHFFFAOYSA-N;DTXSID601284053;AKOS030748342;3-(5-Bromo-thiophen-2-yl)-acrylic Acid;(2E)-3-(5-bromothien-2-yl)acrylic acid

Suppliers and Price of 3-(5-Bromo-thiophen-2-yl)-acrylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 3-(5-Bromo-thiophen-2-yl)-acrylic Acid

Chemical Property:

PSA：65.54000
LogP:2.60840
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:231.91936
Heavy Atom Count:11
Complexity:181

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(SC(=C1)Br)C=CC(=O)O

Technology Process of 3-(5-Bromo-thiophen-2-yl)-acrylic Acid

There total 1 articles about 3-(5-Bromo-thiophen-2-yl)-acrylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 4701-17-1
5-bromo-2-thiophencarboxaldehyde

: 141-82-2
malonic acid

: 29079-97-8
3-(5-Bromo-2-thienyl)acrylic acid

Guidance literature:: With piperidine; pyridine; for 2h; Reflux;

Reference yield:

: 29079-97-8
3-(5-Bromo-2-thienyl)acrylic acid

: 28948-60-9
2-bromothieno[3,2-c]pyridin-4(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 20 °C

2: benzophenone / 250 °C

With benzophenone; diphenyl phosphoryl azide; triethylamine; In toluene;
DOI:10.1016/j.bmcl.2011.06.050

Reference yield:

: 29079-97-8
3-(5-Bromo-2-thienyl)acrylic acid

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 1036226-96-6
3-[5-(4-trifluoromethoxy-phenyl)-thiophen-2-yl]-acrylic acid

Guidance literature:: 3-(5-Bromo-2-thienyl)acrylic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 20 ℃; for 0.166667h;

4-trifluoromethoxyphenylboronic acid; With sodium carbonate; In 1,2-dimethoxyethane; water; at 20 - 95 ℃; for 20h;