4-chloro-2-methyl-6-phenylpyrimidine

Base Information

• Chemical Name: 4-chloro-2-methyl-6-phenylpyrimidine
• CAS No.: 2915-15-3
• Molecular Formula: C11H9ClN2
• Molecular Weight: 204.659
• Mol file: 2915-15-3.mol

Synonyms:4-chloro-2-methyl-6-phenyl-pyrimidine;4-chloro-2-methyl-6-nitro-quinoline;4-Chlor-2-methyl-6-nitro-chinolin;5-Nitro-4-chlor-chinaldin;

Chemical Property of 4-chloro-2-methyl-6-phenylpyrimidine

Chemical Property:

• PSA: 25.78000
• LogP: 3.10540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-chloro-2-methyl-6-phenylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2-methyl-6-phenylpyrimidine

There total 7 articles about 4-chloro-2-methyl-6-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-phenyl-4-hydroxy-2-methylpyrimidine (62260-39-3) → 4-chloro-2-methyl-6-phenyl-pyrimidine (2915-15-3)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 4h;

DOI:10.1002/cmdc.201700243

Reference yield: 96.0%

2-methyl-6-phenylpyrimidin-4(3H)-one (62260-39-3) → 4-chloro-2-methyl-6-phenyl-pyrimidine (2915-15-3)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 2h;

DOI:10.1055/s-1993-25886

Reference yield: 82.0%

2,4-dichloro-2-methylpyrimidine (1780-26-3) + phenylboronic acid (98-80-6) → 4-chloro-2-methyl-6-phenyl-pyrimidine (2915-15-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; toluene; at 90 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.04.022

upstream raw materials:

2-methyl-6-phenylpyrimidin-4(3H)-one

Benzotrichlorid

acetonitrile

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

N,N-dimethyl-2-(2'-methyl-6'-phenylpyrimidin-4'-ylthio)ethylamine

4-Hex-1-ynyl-2-methyl-6-phenyl-pyrimidine

methyl 2-methyl-6-phenyl-4-pyrimidinyl ketone

2,4-dimethyl-6-phenylpyrimidine

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