2H-azepine

Base Information

Chemical Name:2H-azepine
CAS No.:291-68-9
Molecular Formula:C6H7N
Molecular Weight:93.12650
Hs Code.:
DSSTox Substance ID:DTXSID50433344
Nikkaji Number:J39.870E
Mol file:291-68-9.mol

Synonyms:2H-azepine;291-68-9;DTXSID50433344

Suppliers and Price of 2H-azepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2H-azepine

Chemical Property:

PSA：12.36000
LogP:0.61880
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:93.057849228
Heavy Atom Count:7
Complexity:120

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C=CC=CC=N1

Technology Process of 2H-azepine

There total 6 articles about 2H-azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Acetic acid 1-(tert-butoxycarbonylamino-methyl)-5-hydroxy-pent-2-ynyl ester

: 291-68-9
2H-Azepin

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Lindlar catalyst, quinoline / benzene / 3 h / 25 °C / 750.06 Torr

2: 95 percent / Dess-Martin periodinan / CH₂Cl₂ / 0.5 h / 25 °C

3: 1.) TFA, molecular sieves 4 Angstroem, 2.) DABCO / 1.) CDCl₃, -11 deg C, 3.5 h

With 1,4-diaza-bicyclo[2.2.2]octane; 4 A molecular sieve; hydrogen; Dess-Martin periodane; trifluoroacetic acid; quinoline; Lindlar's catalyst; In dichloromethane; benzene;

Reference yield:

: [2-Hydroxy-6-(tetrahydro-pyran-2-yloxy)-hex-3-ynyl]-carbamic acid tert-butyl ester

: 291-68-9
2H-Azepin

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine, DMAP / CH₂Cl₂ / 0.83 h / 25 °C

2: 94 percent / PPTS, glycol / 1,2-dimethoxy-ethane / 2.25 h / 70 °C

3: H₂ / Lindlar catalyst, quinoline / benzene / 3 h / 25 °C / 750.06 Torr

4: 95 percent / Dess-Martin periodinan / CH₂Cl₂ / 0.5 h / 25 °C

5: 1.) TFA, molecular sieves 4 Angstroem, 2.) DABCO / 1.) CDCl₃, -11 deg C, 3.5 h

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; 4 A molecular sieve; hydrogen; pyridinium p-toluenesulfonate; Dess-Martin periodane; ethylene glycol; trifluoroacetic acid; quinoline; Lindlar's catalyst; In 1,2-dimethoxyethane; dichloromethane; benzene;

Reference yield:

: 170748-22-8
[2-Oxo-6-(tetrahydro-pyran-2-yloxy)-hex-3-ynyl]-carbamic acid tert-butyl ester

: 291-68-9
2H-Azepin

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄ / methanol / 1 h / 0 °C

2: pyridine, DMAP / CH₂Cl₂ / 0.83 h / 25 °C

3: 94 percent / PPTS, glycol / 1,2-dimethoxy-ethane / 2.25 h / 70 °C

4: H₂ / Lindlar catalyst, quinoline / benzene / 3 h / 25 °C / 750.06 Torr

5: 95 percent / Dess-Martin periodinan / CH₂Cl₂ / 0.5 h / 25 °C

6: 1.) TFA, molecular sieves 4 Angstroem, 2.) DABCO / 1.) CDCl₃, -11 deg C, 3.5 h

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; sodium tetrahydroborate; 4 A molecular sieve; hydrogen; pyridinium p-toluenesulfonate; Dess-Martin periodane; ethylene glycol; trifluoroacetic acid; quinoline; Lindlar's catalyst; In methanol; 1,2-dimethoxyethane; dichloromethane; benzene;