5-methyl-2-pyridin-2-yl-4H-pyrazol-3-one

Base Information

• Chemical Name: 5-methyl-2-pyridin-2-yl-4H-pyrazol-3-one
• CAS No.: 29211-49-2
• Molecular Formula: C9H9N3O
• Molecular Weight: 175.19
• European Community (EC) Number: 843-133-7
• Nikkaji Number: J554.555B
• ChEMBL ID: CHEMBL374252
• Mol file: 29211-49-2.mol

Synonyms:29211-49-2;5-methyl-2-pyridin-2-yl-4H-pyrazol-3-one;3-Methyl-1-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-5-one;2,4-dihydro-5-methyl-2-(2-pyridinyl)-3H-Pyrazol-3-one;CHEMBL374252;5-methyl-2-(pyridin-2-yl)-2,4-dihydro-3H-pyrazol-3-one;SCHEMBL3886681;YRMYSKQWKJIJMR-UHFFFAOYSA-N;BDBM50605275;STL279994;AKOS002309898;FT-0757086;EN300-312302;Z50146949;2,4-dihydro-5-methyl-2-(2-pyridyl)-3H-pyrazol-3-one;5-methyl-2-(2-pyridinyl)-2,4-dihydro-3H-pyrazol-3-one

Chemical Property of 5-methyl-2-pyridin-2-yl-4H-pyrazol-3-one

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 175.074561919
• Heavy Atom Count: 13
• Complexity: 249

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NN(C(=O)C1)C2=CC=CC=N2

Technology Process of 5-methyl-2-pyridin-2-yl-4H-pyrazol-3-one

There total 1 articles about 5-methyl-2-pyridin-2-yl-4H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrid-2-ylhydrazine (4930-98-7) → ethyl acetoacetate (141-97-9) + 2,4-dihydro-5-methyl-2-(pyridin-2-yl)-3H-pyrazol-3-one (29211-49-2)

Guidance literature:

Reference yield: 82.0%

2,4-dihydro-5-methyl-2-(pyridin-2-yl)-3H-pyrazol-3-one (29211-49-2) + 4-dimethylamino-benzaldehyde (100-10-7) → (Z)-4-(4-(dimethylamino)benzylidene)-3-methyl-1-(pyridin-2-yl)-1H-pyrazol-5(4H)-one (1209495-19-1)

Guidance literature:

for 0.1h; Microwave irradiation;

DOI:10.1039/b9nj00442d

Reference yield: 55.0%

2,4-dihydro-5-methyl-2-(pyridin-2-yl)-3H-pyrazol-3-one (29211-49-2) + 4-dimethylamino-benzaldehyde (100-10-7) → (4E)-4-[4-(dimethylamino)-benzylidene]-5-methyl-2-(2-pyridinyl)-2,4-dihydro-3H-pyrazol-3-one (874989-60-3)

Guidance literature:

With piperidine; In ethanol; for 2h; Heating / reflux;

upstream raw materials:

pyrid-2-ylhydrazine

Downstream raw materials:

(4E)-4-[4-(dimethylamino)-benzylidene]-5-methyl-2-(2-pyridinyl)-2,4-dihydro-3H-pyrazol-3-one

3-methyl-5-phenoxy-1-pyridin-2-yl-1H-pyrazole-4-carbaldehyde oxime

(4E)-4-[4-hydroxy-3-methoxybenzylidene]-5-methyl-2-(2-pyridinyl)-2,4-dihydro-3H-pyrazol-3-one

(Z)-4-(4-(dimethylamino)benzylidene)-3-methyl-1-(pyridin-2-yl)-1H-pyrazol-5(4H)-one