Cinnoline, 4-(3-nitrophenyl)-

Base Information

Chemical Name:Cinnoline, 4-(3-nitrophenyl)-
CAS No.:297133-99-4
Molecular Formula:C14H9N3O2
Molecular Weight:251.244
Hs Code.:
Mol file:297133-99-4.mol

Synonyms:

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Chemical Property of Cinnoline, 4-(3-nitrophenyl)-

Chemical Property:

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Technology Process of Cinnoline, 4-(3-nitrophenyl)-

There total 4 articles about Cinnoline, 4-(3-nitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 5152-84-1
4-chlorocinnoline

: 13331-27-6
m-nitrobenzene boronic acid

: 297133-99-4
4-(3'-nitrophenyl)cinnoline

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; for 40h; Heating;
DOI:10.1016/S0040-4020(00)00448-8

Reference yield:

: 615-43-0
2-iodophenylamine

: 297133-99-4
4-(3'-nitrophenyl)cinnoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / Et₃N; CuI / Pd*PPh₃)2Cl₂ / 24 h / Heating

2.1: NaNO₂; 6N HCl / H₂O / 0.5 h / 0 °C

2.2: 73 percent / 3 h / Heating

3.1: 77 percent / POCl₃ / pyridine; chlorobenzene / 1 h / Heating

4.1: 88 percent / 2M K₂CO₃ / Pd(PPh₃)4 / H₂O; ethanol; 1,2-dimethoxy-ethane / 40 h / Heating

With hydrogenchloride; copper(l) iodide; potassium carbonate; triethylamine; sodium nitrite; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine; 1,2-dimethoxyethane; ethanol; water; chlorobenzene; 1.1: Substitution / 2.1: Diazotization / 2.2: Cyclization / 3.1: Chlorination / 4.1: Suzuki coupling;
DOI:10.1016/S0040-4020(00)00448-8

Reference yield:

: 103529-16-4
2-[(trimethylsilyl)ethynyl]aniline

: 297133-99-4
4-(3'-nitrophenyl)cinnoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaNO₂; 6N HCl / H₂O / 0.5 h / 0 °C

1.2: 73 percent / 3 h / Heating

2.1: 77 percent / POCl₃ / pyridine; chlorobenzene / 1 h / Heating

3.1: 88 percent / 2M K₂CO₃ / Pd(PPh₃)4 / H₂O; ethanol; 1,2-dimethoxy-ethane / 40 h / Heating

With hydrogenchloride; potassium carbonate; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In pyridine; 1,2-dimethoxyethane; ethanol; water; chlorobenzene; 1.1: Diazotization / 1.2: Cyclization / 2.1: Chlorination / 3.1: Suzuki coupling;
DOI:10.1016/S0040-4020(00)00448-8