N-(4-chlorophenyl)-2-phenylacetamide

Base Information

• Chemical Name: N-(4-chlorophenyl)-2-phenylacetamide
• CAS No.: 2990-06-9
• Molecular Formula: C14H12ClNO
• Molecular Weight: 245.708
• DSSTox Substance ID: DTXSID80352337
• Nikkaji Number: J418.106I
• Wikidata: Q82129413
• Mol file: 2990-06-9.mol

Synonyms:N-(4-chlorophenyl)-2-phenylacetamide;2990-06-9;starbld0030362;Maybridge1_008792;4'-chlorophenylacetanilide;SCHEMBL10750201;HMS566H14;DTXSID80352337;CCG-41005;AKOS001288412;Benzenacetamide, N-(4-chlorophenyl)-;AO-548/40072459;SR-01000631111-1;BRD-K20050899-001-01-8;Z28161806

Chemical Property of N-(4-chlorophenyl)-2-phenylacetamide

Chemical Property:

• PSA: 29.10000
• LogP: 3.59420
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 245.0607417
• Heavy Atom Count: 17
• Complexity: 243

Purity/Quality:

99% ^*data from raw suppliers

N-(4-CHLOROPHENYL)-2-PHENYLACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(=O)NC2=CC=C(C=C2)Cl

Technology Process of N-(4-chlorophenyl)-2-phenylacetamide

There total 18 articles about N-(4-chlorophenyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

→ N-(4-chlorophenyl)-2-phenylacetamide (2990-06-9)

Guidance literature:

With pyridine; for 4h; Cooling with ice; Reflux;

Reference yield: 92.0%

phenylacetic acid (103-82-2) + 4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-2-phenylacetamide (2990-06-9)

Guidance literature:

With Fe⁽³⁺⁾-K-10 montmorillonite clay; In chloroform; for 7h; Heating;

DOI:10.1021/jo0204202

Reference yield: 92.0%

4-chloro-aniline (106-47-8) + (isopropylideneamino) 2-phenylacetate → N-(4-chlorophenyl)-2-phenylacetamide (2990-06-9)

Guidance literature:

With CAL-B; In tert-butyl methyl ether; at 55 ℃; for 8h; chemoselective reaction; Green chemistry; Enzymatic reaction;

DOI:10.1039/c3ra46499g

upstream raw materials:

p-chloroaniline hydrochloride

phenylacetonitrile

phenylacetic acid

4-chloro-aniline

Downstream raw materials:

3-chloro-1-(4-chlorophenyl)-4-phenyl-1H-pyrrole-2,5-dione

N-(4-chlorophenyl)-α-oxophenylacetamide

4-chloro-N-methyl-N-phenethylaniline

N-(4-chlorophenyl)-N-(2-phenylethyl)amine