O-{[4-(trifluoromethyl)phenyl]methyl}hydroxylamine

Base Information

Chemical Name:O-{[4-(trifluoromethyl)phenyl]methyl}hydroxylamine
CAS No.:2993-57-9
Molecular Formula:C8H8F3NO
Molecular Weight:191.153
Hs Code.:
DSSTox Substance ID:DTXSID60372235
Wikidata:Q82159825
ChEMBL ID:CHEMBL3765985

Synonyms:O-{[4-(trifluoromethyl)phenyl]methyl}hydroxylamine;2993-57-9;O-[[4-(trifluoromethyl)phenyl]methyl]hydroxylamine;o-(4-(trifluoromethyl)benzyl)hydroxylamine;SCHEMBL1520538;CHEMBL3765985;DTXSID60372235;EN300-114647;Z2242062134

Suppliers and Price of O-{[4-(trifluoromethyl)phenyl]methyl}hydroxylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of O-{[4-(trifluoromethyl)phenyl]methyl}hydroxylamine

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:191.05579836
Heavy Atom Count:13
Complexity:152

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CON)C(F)(F)F

Technology Process of O-{[4-(trifluoromethyl)phenyl]methyl}hydroxylamine

There total 3 articles about O-{[4-(trifluoromethyl)phenyl]methyl}hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-((4-(trifluoromethyl)benzyl)oxy)isoindoline-1,3-dione

: 2993-57-9
O-(4-(trifluoromethyl)benzyl)hydroxylamine

Guidance literature:: With hydrazine hydrate; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2015.12.028

Reference yield:

: 939-99-1
4-trifluoromethylbenzyl chloride

: 2993-57-9
O-(4-(trifluoromethyl)benzyl)hydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: hydrazine hydrate / 2 h / 20 °C / Inert atmosphere

With hydrazine hydrate; triethylamine; In dichloromethane;
DOI:10.1039/c9ob00045c

Reference yield:

: 349-95-1
4-(trifluoromethyl)benzylic alcohol

: 2993-57-9
O-(4-(trifluoromethyl)benzyl)hydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: hydrazine hydrate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; 1: |Mitsunobu Displacement;
DOI:10.1016/j.ejmech.2015.12.028