N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide
CAS No.:30069-31-9
Molecular Formula:C15H13F3N2O
Molecular Weight:294.276
Hs Code.:
European Community (EC) Number:869-784-7
DSSTox Substance ID:DTXSID30468114
Wikidata:Q82295217
Mol file:30069-31-9.mol

Synonyms:N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide;30069-31-9;N-(3-Amino-4-methyl-phenyl)-3-trifluoromethyl-benzamide;SCHEMBL374471;C15H13F3N2O;DTXSID30468114;TQP0940;XOFRFSPSRHTALR-UHFFFAOYSA-N;BCP29201;AKOS000171576;AC-33898;BS-52120;CS-0251769;EN300-56001;E87364;N-(3-amino-4-methylphenyl)-3-trifluoromethylbenzamide;N-(3-amino-4-methyl-phenyl)-3-trifluoromethylbenzamide;N-(3-amino-4-methylphenyl)-3-trifluoromethyl-benzamide;Z295382362

Suppliers and Price of N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-(3-AMINO-4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE 95.00%
5G
$ 1295.03

American Custom Chemicals Corporation
N-(3-AMINO-4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE 95.00%
2.5G
$ 1065.66

American Custom Chemicals Corporation
N-(3-AMINO-4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE 95.00%
1G
$ 765.23

AK Scientific
N-(3-Amino-4-methylphenyl)-3-(trifluoromethyl)benzamide
1g
$ 387.00

AK Scientific
N-(3-Amino-4-methylphenyl)-3-(trifluoromethyl)benzamide
500mg
$ 289.00

Total 7 raw suppliers

Chemical Property of N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

Chemical Property:

Boiling Point:338.4±42.0 °C(Predicted)
PKA:12.88±0.70(Predicted)
PSA：58.61000
Density:1.335±0.06 g/cm3(Predicted)
LogP:4.81350
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:294.09799753
Heavy Atom Count:21
Complexity:372

Purity/Quality:

99%, ^*data from raw suppliers

N-(3-AMINO-4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N

Technology Process of N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

There total 8 articles about N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 221876-21-7
N-(4-methyl-3-nitrophenyl)-3-(trifluoromethyl)benzamide

: 30069-31-9
N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield:

: 119-32-4
4-Methyl-3-nitroanilin

: 30069-31-9
N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 60 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 4 h

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 30069-31-9
N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 15 h / 25 °C / Inert atmosphere; Schlenk technique

2: palladium 10% on activated carbon; hydrogen / methanol / 25 °C / Inert atmosphere; Schlenk technique

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm5009242