tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate
• CAS No.: 301232-45-1
• Molecular Formula: C₁₅H₂₇NO₄
• Molecular Weight: 285.384
• Hs Code.: 2933399090
• Mol file: 301232-45-1.mol

Synonyms:RW3836;Tert-Butyl 4-(3-Ethoxy-3-Oxopropyl)Piperidine-1-Carboxylate;QC-3349;

Chemical Property of tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

Chemical Property:

• PSA: 55.84000
• Density: 1.036
• LogP: 2.91470
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-piperidinepropanoicacidethylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate

There total 11 articles about tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 3-(piperid-4-yl)propionate (71879-55-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(3-ethoxy-3-oxopropyl)-1-piperidinecarboxylate (301232-45-1)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 20 ℃; for 96h;

DOI:10.3987/com-01-9213

Reference yield: 81.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl 3-(4-piperidinyl)propanoate hydrochloride (473987-06-3) → tert-butyl 4-(3-ethoxy-3-oxopropyl)-1-piperidinecarboxylate (301232-45-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.bmc.2005.03.056

Reference yield: 62.0%

ethyl (triphenylphosphoranylidene)acetate (1099-45-2) + tert butyl 4-formylpiperidine-1-carboxylate (137076-22-3) → tert-butyl 4-(3-ethoxy-3-oxopropyl)-1-piperidinecarboxylate (301232-45-1)

Guidance literature:

With N,N-dimethyl acetamide; palladium 10% on activated carbon; hydrogen; In ethanol; water; at 20 ℃; for 91h; under 760.051 Torr; chemoselective reaction;

DOI:10.1021/acs.orglett.0c01874

upstream raw materials:

ethyl 3-(piperid-4-yl)propionate

di-tert-butyl dicarbonate

t-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-tetrahydropyridine-1(2H)-carboxylate

ethyl 3-(4-piperidinyl)propanoate hydrochloride

Downstream raw materials:

N-hydroxy-3-(1-phenylmethanesulfonyl-piperidin-4-yl)-propionamide

3-(1-benzenesulfonyl-piperidin-4-yl)-N-hydroxy-propionamide

3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide

N-hydroxy-3-(1-phenylacetyl-piperidin-4-yl)-propionamide