1-[4-Chloro-6-methyl-2-pyrimidyl]-3-[3,4-dichlorophenyl]guanidine

Base Information

• Chemical Name: 1-[4-Chloro-6-methyl-2-pyrimidyl]-3-[3,4-dichlorophenyl]guanidine
• CAS No.: 51387-79-2
• Molecular Formula: C12H10Cl3N5
• Molecular Weight: 330.6003
• NSC Number: 139605
• DSSTox Substance ID: DTXSID30965693

Synonyms:51387-79-2;NSC139605;SCHEMBL17985492;DTXSID30965693;1-[4-Chloro-6-methyl-2-pyrimidyl]-3-[3,4-dichlorophenyl]guanidine;NSC-139605;N-(4-Chloro-6-methyl-2-pyrimidinyl)-N'-(3,4-dichlorophenyl)guanidine #;N-(4-Chloro-6-methylpyrimidin-2-yl)-N'-(3,4-dichlorophenyl)guanidine

Chemical Property of 1-[4-Chloro-6-methyl-2-pyrimidyl]-3-[3,4-dichlorophenyl]guanidine

Chemical Property:

• Vapor Pressure: 1.45E-10mmHg at 25°C
• Boiling Point: 511.2°C at 760 mmHg
• Flash Point: 263°C
• Density: 1.56g/cm³
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 329.000178
• Heavy Atom Count: 20
• Complexity: 354

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)N=C(N)NC2=CC(=C(C=C2)Cl)Cl)Cl
• Isomeric SMILES: CC1=CC(=NC(=N1)/N=C(\N)/NC2=CC(=C(C=C2)Cl)Cl)Cl

Technology Process of 1-[4-Chloro-6-methyl-2-pyrimidyl]-3-[3,4-dichlorophenyl]guanidine

There total 1 articles about 1-[4-Chloro-6-methyl-2-pyrimidyl]-3-[3,4-dichlorophenyl]guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-[3-(3,4-dichlorophenyl)guanidino]-6-methyl-4-pyrimidinol → 3-(4-Chloro-6-methyl-2-pyrimidinyl)-1-(3,4-dichlorophenyl)guanidine (51387-79-2)

Guidance literature:

With trichlorophosphate; at 0 - 90 ℃; for 4.75h; Inert atmosphere;

Reference yield:

3-(4-Chloro-6-methyl-2-pyrimidinyl)-1-(3,4-dichlorophenyl)guanidine (51387-79-2) → 4-[(3R)-1-ethyl-3-piperidylamino]-2-[3-(3,4-dichlorophenyl)guanidino]-6-methyl-pyrimidine

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / N,N-dimethyl acetamide / 18 h / 90 °C

2: hydrogenchloride / methanol; 1,4-dioxane / 20 °C

3: sodium cyanoborohydride / dichloromethane

With hydrogenchloride; sodium cyanoborohydride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

3-(4-Chloro-6-methyl-2-pyrimidinyl)-1-(3,4-dichlorophenyl)guanidine (51387-79-2) → 1-(3,4-dichlorophenyl)-3-[6-methyl-4-(3-piperidyloxy)-2-pyrimidinyl]guanidine

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 20 °C / Inert atmosphere

1.2: 24 h / 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 5 h / 20 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; mineral oil;

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 51387-79-2 2-(4-chloro-6-methylpyrimidin-2-yl)-1-(3,4-dichlorophenyl)guanidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send