4-(3-Chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile

Base Information

Chemical Name:4-(3-Chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile
CAS No.:305371-33-9
Molecular Formula:C15H7ClF2N4
Molecular Weight:316.697
Hs Code.:2933990090
DSSTox Substance ID:DTXSID40595021
Wikidata:Q82489954
Mol file:305371-33-9.mol

Synonyms:305371-33-9;4-(3-CHLORO-4-FLUOROPHENYLAMINO)-6-FLUORO-1,7-NAPHTHYRIDINE-3-CARBONITRILE;4-(3-chloro-4-fluoroanilino)-6-fluoro-1,7-naphthyridine-3-carbonitrile;4-((3-Chloro-4-fluorophenyl)amino)-6-fluoro-1,7-naphthyridine-3-carbonitrile;4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-FLUORO-1,7-NAPHTHYRIDINE-3-CARBONITRILE;SCHEMBL4766964;DTXSID40595021;QONCFNVAJYDZDL-UHFFFAOYSA-N;AT23726;DB-304988;4-(3-Chloro-4-fluoro-phenylamino)-6-fluoro-[1,7]naphthyridine-3-carbonitrile;4-(3-chloro-4-fluoro-phenylamino)-6-fluoro-[1.7]naphthyridine-3-carbonitrile

Suppliers and Price of 4-(3-Chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-(3-Chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile

Chemical Property:

PSA：64.83000
LogP:3.59858
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:316.0327303
Heavy Atom Count:22
Complexity:443

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1NC2=C(C=NC3=CN=C(C=C32)F)C#N)Cl)F

Technology Process of 4-(3-Chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile

There total 6 articles about 4-(3-Chloro-4-fluorophenylamino)-6-fluoro-1,7-naphthyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 367-21-5
3-chloro-4-fluorophenylamine

: 305371-18-0
4-chloro-6-fluoro-[1,7]naphthyridine-3-carbonitrile

: 305371-33-9
4-(3-chloro-4-fluorophenylamino)-6-fluoro-[1,7]naphthyridine-3-carbonitrile

Guidance literature:: In ethanol; for 2h; Heating / reflux;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 305371-33-9
4-(3-chloro-4-fluorophenylamino)-6-fluoro-[1,7]naphthyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: 84 percent / KF / dimethylsulfoxide / 18 h / 70 °C

2.1: 70 percent / H₂ / Raney Ni / ethyl acetate

3.1: 96 percent / 2-methyl-propan-2-ol / 4 h / 40 °C

4.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 °C

4.2: diethyl ether

5.1: methanol; CHCl₃; hexane / 2 h / 0 - 20 °C

6.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

6.2: AcOH / tetrahydrofuran / -78 - 20 °C

7.1: dimethylformamide / 5 h / 20 °C

8.1: 70 percent / (COCl)2; DMF / CH₂Cl₂ / 2 h / Heating

9.1: ethanol / 8 h / Heating

With potassium fluoride; n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; hydrogen; N,N-dimethyl-formamide; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2004.01.034

Reference yield:

: 456-24-6
2-Fluoro-5-nitropyridine

: 305371-33-9
4-(3-chloro-4-fluorophenylamino)-6-fluoro-[1,7]naphthyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: 70 percent / H₂ / Raney Ni / ethyl acetate

2.1: 96 percent / 2-methyl-propan-2-ol / 4 h / 40 °C

3.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 °C

3.2: diethyl ether

4.1: methanol; CHCl₃; hexane / 2 h / 0 - 20 °C

5.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

5.2: AcOH / tetrahydrofuran / -78 - 20 °C

6.1: dimethylformamide / 5 h / 20 °C

7.1: 70 percent / (COCl)2; DMF / CH₂Cl₂ / 2 h / Heating

8.1: ethanol / 8 h / Heating

With n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; hydrogen; N,N-dimethyl-formamide; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2004.01.034