Cyclohexanecarboxylic acid, 1-[[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]-3-methylbutyl]amino]carbonyl] amino]-, methyl ester

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 1-[[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]-3-methylbutyl]amino]carbonyl] amino]-, methyl ester
• CAS No.: 306768-96-7
• Molecular Formula: C19H34N2O5
• Molecular Weight: 370.489
• Mol file: 306768-96-7.mol

Synonyms:

Chemical Property of Cyclohexanecarboxylic acid, 1-[[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]-3-methylbutyl]amino]carbonyl] amino]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxylic acid, 1-[[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]-3-methylbutyl]amino]carbonyl] amino]-, methyl ester

There total 3 articles about Cyclohexanecarboxylic acid, 1-[[[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]-3-methylbutyl]amino]carbonyl] amino]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

methyl 1-aminocyclohexanecarboxylate (4507-57-7) + L-leucine t-butyl ester isocyanate → (2S)-1-[3-(1-t-butoxycarbonyl-3-methylbutyl)ureido]cyclohexane-1-carboxylic acid methyl ester (306768-96-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1055/s-2002-34389

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → (2S)-1-[3-(1-t-butoxycarbonyl-3-methylbutyl)ureido]cyclohexane-1-carboxylic acid methyl ester (306768-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: SOCl₂ / 5 h / 20 °C

1.2: 66 percent / aq. Na₂CO₃ / pH 9

2.1: 69 percent / dimethylformamide / 2 h / 20 °C

With thionyl chloride; In N,N-dimethyl-formamide;

DOI:10.1055/s-2002-34389

Reference yield:

→ (2S)-1-[3-(1-t-butoxycarbonyl-3-methylbutyl)ureido]cyclohexane-1-carboxylic acid methyl ester (306768-96-7)

Guidance literature:

upstream raw materials:

methyl 1-aminocyclohexanecarboxylate

1-aminocyclohexane carboxylic acid

Downstream raw materials:

(3S)-(3,4-dimethoxyphenyl)-3-[(2S)-{2,4-dioxo-1-[4-(3-phenylureido)benzyl]-1,3-diazaspiro[4.5]dec-3-yl}-4-methylpentanoylamino]propionic acid

(2S)-{2,4-dioxo-1-[4-(3-phenylureido)benzyl]-1,3-diazaspiro[4.5]dec-3-yl}-4-methylpentanoic acid