2H-2-Benzazepine-2-acetic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-8-hydroxy- 3-oxo-, (4S)-

Base Information

• Chemical Name: 2H-2-Benzazepine-2-acetic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-8-hydroxy- 3-oxo-, (4S)-
• CAS No.: 306775-48-4
• Molecular Formula: C20H16N2O6
• Molecular Weight: 380.357
• Mol file: 306775-48-4.mol

Synonyms:

Chemical Property of 2H-2-Benzazepine-2-acetic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-8-hydroxy- 3-oxo-, (4S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-2-Benzazepine-2-acetic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-8-hydroxy- 3-oxo-, (4S)-

There total 2 articles about 2H-2-Benzazepine-2-acetic acid, 4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-8-hydroxy- 3-oxo-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-[2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-(4-benzyloxyphenyl)propanoyl]-1,3-oxazolidin-5-one (306775-46-2) → 4(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-80hydroxy-3-oxo-2Hbenzazepin-2-acetic acid (306775-48-4) + 4(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-7-benzyl-8-hydroxy-3-oxo-2H-benzazepin-2-acetic acid

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 4h; Further Variations:; Temperatures; reaction times; Product distribution; Heating;

DOI:10.1021/jo000530d

Reference yield: 13.0%

3-[2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-(4-benzyloxyphenyl)propanoyl]-1,3-oxazolidin-5-one (306775-46-2) → 2-[4(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,2,4,5-tetrahydro-2-azin-3-one-6-spiro-1'-cyclohexa-2',5'-dien-4'-one]acetic acid + 4(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-80hydroxy-3-oxo-2Hbenzazepin-2-acetic acid (306775-48-4) + 4(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1,3,4,5-tetrahydro-8-benzyloxy-3-oxo-2H-benzazepin-2-acetic acid

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 0 - 20 ℃; for 24.5h;

DOI:10.1021/jo000530d

upstream raw materials:

3-[2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-(4-benzyloxyphenyl)propanoyl]-1,3-oxazolidin-5-one