2-(hydroxymethyl)ethisterone

Base Information

• Chemical Name: 2-(hydroxymethyl)ethisterone
• CAS No.: 2787-03-3
• Molecular Formula: C₂₂H₃₀O₃
• Molecular Weight: 342.478
• Mol file: 2787-03-3.mol

Synonyms:17a-Pregn-4-en-20-yn-3-one,17-hydroxy-2a-(hydroxymethyl)-(7CI,8CI)

Chemical Property of 2-(hydroxymethyl)ethisterone

Chemical Property:

• Vapor Pressure: 5.42E-12mmHg at 25°C
• Boiling Point: 497.7°Cat760mmHg
• Flash Point: 268.9°C
• PSA: 57.53000
• Density: 1.18g/cm³
• LogP: 3.10100

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A derivative of Danazol (D145000).

Technology Process of 2-(hydroxymethyl)ethisterone

There total 6 articles about 2-(hydroxymethyl)ethisterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

17α-ethynyl-2α-hydroxymethyl-4-androstene-3β,17β-diol (107575-29-1) → 17α-ethynyl-17β-hydroxy-2α-hydroxymethyl-4-androsten-3-one (2787-03-3)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 3h; Ambient temperature;

Reference yield: 12.6%

danazol (17230-88-5) → 17α-ethynyl-17β-hydroxy-2α-hydroxymethyl-4-androsten-3-one (2787-03-3)

Guidance literature:

With ammonium nitrate; magnesium sulfate heptahydrate; D-glucose; potassium phosphate; In dimethyl sulfoxide; for 288h; Microbiological reaction; aq. buffer;

DOI:10.3906/kim-0912-400

Reference yield: 10.8%

danazol (17230-88-5) → 17β-hydroxy-2-(hydroxymethyl)-17α-pregna-1,4-dien-20-yn-3-one (60142-08-7) + 17α-ethynyl-17β-hydroxy-2α-hydroxymethyl-4-androsten-3-one (2787-03-3)

Guidance literature:

With D-glucose; potassium phosphate; glycerol; sodium chloride; In dimethyl sulfoxide; for 288h; Microbiological reaction; aq. buffer;

DOI:10.3906/kim-0912-400

upstream raw materials:

17α-ethynyl-2α-hydroxymethyl-4-androstene-3β,17β-diol

17α-ethenyl-17β-hydroxy-2-hydroxymethylene-4-androsten-3-one

danazol

Refernces

• 1、 Vincze, Iren,Somlai, Csaba,Schneider, Gyula,Dombi, Gyoergy,Kalman, Alajos. "2-(Hydroxymethyl)androstene Derivatives". . p. 499 - 504. Retrieved 2007/10/02.