1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-methyl-

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-methyl-
• CAS No.: 307951-53-7
• Molecular Formula: C8H7ClN2
• Molecular Weight: 166.61
• Hs Code.: 2933990090
• Mol file: 307951-53-7.mol

Synonyms:4-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine;4-Chloro-2-methyl-7-azaindole;

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-methyl-

Chemical Property:

• Melting Point: 173-178°C
• PSA: 28.68000
• LogP: 2.52470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4-Chloro-2-methyl-7-azaindole 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-methyl-

There total 2 articles about 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-chloro-2-methyl-1-(o-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (744209-64-1) → 4-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine (307951-53-7)

Guidance literature:

With potassium carbonate; In methanol; water; for 16h; Heating;

DOI:10.1016/j.tetlet.2008.04.063

Reference yield: 86.0%

4-chloro-1-((4-ethylphenyl)sulfonyl)-2-methyl-1H-pyrrolo[2,3-b]pyridine → 4-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine (307951-53-7)

Guidance literature:

With sodium hydroxide; In methanol; at 70 ℃; for 5h;

Reference yield: 95.0%

4-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine (307951-53-7) + p-toluenesulfonyl chloride (98-59-9) → 4-chloro-2-methyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:

4-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.75h; Inert atmosphere;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; for 0.333333h;

upstream raw materials:

4-chloro-2-methyl-1-(o-tolylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

C₁₄H₁₈BClN₂O₂

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