5,6-DIMETHYL-1H-INDOLE

Base Information

• Chemical Name: 5,6-DIMETHYL-1H-INDOLE
• CAS No.: 30877-30-6
• Molecular Formula: C10H11N
• Molecular Weight: 145.204
• Hs Code.: 2933990090
• Mol file: 30877-30-6.mol

Synonyms:1H-Indole, 5,6-dimethyl-;dimethylindole;5,6-Dimethyl-indazol;5,6-Dimethyl 1H-indole;5,6-Dimethyl-indol;2,3-Dimethyl-indol;5,6-dimethyl-indole;

Chemical Property of 5,6-DIMETHYL-1H-INDOLE

Chemical Property:

• Melting Point: 154-155 °C
• Boiling Point: 198 °C(Press: 8 Torr)
• PKA: 17.53±0.30(Predicted)
• PSA: 15.79000
• Density: 1.080±0.06 g/cm3(Predicted)
• LogP: 2.78470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5,6-Dimethyl-1H-indole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DIMETHYL-1H-INDOLE

There total 8 articles about 5,6-DIMETHYL-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5,6-dimethyl-2,3-dihydro-1H-indole (791609-49-9) → 5,6-dimethyl-indole (30877-30-6)

Guidance literature:

With manganese(IV) oxide; 4 A molecular sieve; In benzene; at 40 - 50 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.08.110

Reference yield: 40.0%

N-(2,4,5-trimethylphenyl)formamide (858244-30-1) → 5,6-dimethyl-indole (30877-30-6)

Guidance literature:

With potassium tert-butylate; at 270 - 280 ℃;

DOI:10.1081/NCN-200067398

Reference yield:

4-amino-o-xylene (95-64-7) → 5,6-dimethyl-indole (30877-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / NaHCO₃ / aq. ethanol / 96 h / Heating

2: 2) KOH / 1) CF₃COOH, 0 deg C, 30 min, then reflux 70 h; 2) MeOH, room temperature

With potassium hydroxide; sodium hydrogencarbonate; In ethanol;

DOI:10.1021/jo00317a026

upstream raw materials:

N-(2,4,5-trimethylphenyl)formamide

N-(2,2-Diethoxy-ethyl)-N-(3,4-dimethyl-phenyl)-2,2,2-trifluoro-acetamide

(2,2-Diethoxy-ethyl)-(3,4-dimethyl-phenyl)-amine

trifluoroacetic anhydride

Downstream raw materials:

(5,6-dimethyl-1H-indol-3-yl)(phenyl)methanone

1-((3aR,4S,6R,6aR)-2,2-Dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-5,6-dimethyl-1H-indole

1-(5-O-triphenylmethyl-2,3-O-isopropylidene-α-D-ribofuranosyl) 5,6-dimethylindoline

Refernces

• 1、 Brown, Kenneth L.,Chandra, Tilak,Zou, Shawn,Valente, Edward J.. "Regioselective glycosylation: Synthesis of α-indoline nucleosides". . p. 1147 - 1165. Retrieved 2007/10/03.
• 2、 Nordlander, J. Eric,Catalane, David B.,Kotian, Kirtivan D.,Stevens, Randall M.,Haky, Jerome E.. "SYNTHESIS OF INDOLES FROM N-(TRIFLUOROACETYL)-2-ANILINO ACETALS". . p. 778 - 782. Retrieved 2007/10/02.