(R)-Nitrendipine

Base Information

• Chemical Name: (R)-Nitrendipine
• CAS No.: 80890-07-9
• Molecular Formula: C₁₈H₂₀N₂O₆
• Molecular Weight: 360.367
• Mol file: 80890-07-9.mol

Synonyms:Lopac-N-144;R-nitrendipine;Tocris-0601;

Chemical Property of (R)-Nitrendipine

Chemical Property:

• Vapor Pressure: 1.04E-09mmHg at 25°C
• Boiling Point: 488.9°C at 760 mmHg
• Flash Point: 249.5°C
• PSA: 110.45000
• Density: 1.247g/cm³
• LogP: 3.41770

Purity/Quality:

99%min ^*data from raw suppliers

(+)-Nitrendipine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (+)-Nitrendipine is used in the treatment of hypertension for the regulation of blood pressure. A dihydropyridine calcium channel blocker.

Technology Process of (R)-Nitrendipine

There total 1 articles about (R)-Nitrendipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester (39562-70-4) → (+)-Nitrendipine (80890-07-9) + (-)-Nitrendipine (80873-62-7)

Guidance literature:

With α₁-acid glycoprotein HPLC column;

DOI:10.1002/(SICI)1522-2675(20000412)83:4<767::AID-HLCA767>3.0.CO;2-#

Reference yield:

(+)-Nitrendipine (80890-07-9) → (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl) ester 5-methyl ester (138135-46-3)

Guidance literature:

With Krebs-Ringer buffer pH 7.4; albumin; at 37 ℃; for 3h; rat hepatocytes;

upstream raw materials:

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Downstream raw materials:

(R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((2S,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl) ester 5-methyl ester

Refernces