L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester

Base Information

• Chemical Name: L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester
• CAS No.: 311346-76-6
• Molecular Formula: C11H13FN2O4
• Molecular Weight: 256.234
• Mol file: 311346-76-6.mol

Synonyms:

Chemical Property of L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester

There total 1 articles about L-Alanine, N-(4-fluoro-2-nitrophenyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

1,4-difluoro-2-nitrobenzene (364-74-9) + (S)-alanine ethyl ester hydrochloride (1115-59-9) → ethyl 2-((4-fluoro-2-nitrophenyl)amino)propanoate (311346-76-6)

Guidance literature:

With pyridine; triethylamine; at 80 ℃; for 17h; Inert atmosphere;

DOI:10.3390/molecules26030646

Reference yield:

ethyl 2-((4-fluoro-2-nitrophenyl)amino)propanoate (311346-76-6) → 6-(benzyloxy)-2-methylquinoxaline

Guidance literature:

Multi-step reaction with 4 steps

1.1: tin(II) chloride dihdyrate / ethanol; water / 1 h / Reflux

1.2: 20 °C

2.1: trichlorophosphate / N,N-dimethyl-aniline / 1 h / 110 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 2 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; sodium hydride; triethylamine; trichlorophosphate; In ethanol; water; N,N-dimethyl-aniline; N,N-dimethyl-formamide; mineral oil;

DOI:10.3390/molecules26030646

Reference yield:

ethyl 2-((4-fluoro-2-nitrophenyl)amino)propanoate (311346-76-6) → (E)-6-(benzyloxy)-2-(3,5-bis(benzyloxy)styryl)quinoxaline

Guidance literature:

Multi-step reaction with 5 steps

1.1: tin(II) chloride dihdyrate / ethanol; water / 1 h / Reflux

1.2: 20 °C

2.1: trichlorophosphate / N,N-dimethyl-aniline / 1 h / 110 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 2 h / 100 °C / Inert atmosphere

5.1: iron(II) acetate; trifluoroacetic acid / toluene / 24 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; iron(II) acetate; sodium hydride; triethylamine; trifluoroacetic acid; trichlorophosphate; In ethanol; water; N,N-dimethyl-aniline; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.3390/molecules26030646

upstream raw materials:

1,4-difluoro-2-nitrobenzene

(S)-alanine ethyl ester hydrochloride