Benzamide, N-[[4-(4-fluorophenoxy)phenyl]methyl]-2-methoxy-5-[(2S)-2-[[(4R)-2-oxo- 4-(phenylmethyl)-3-oxazolidinyl]carbonyl]butyl]-

Base Information

Chemical Name:Benzamide, N-[[4-(4-fluorophenoxy)phenyl]methyl]-2-methoxy-5-[(2S)-2-[[(4R)-2-oxo- 4-(phenylmethyl)-3-oxazolidinyl]carbonyl]butyl]-
CAS No.:311771-85-4
Molecular Formula:C36H35FN2O6
Molecular Weight:610.682
Hs Code.:
Mol file:311771-85-4.mol

Synonyms:

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Chemical Property of Benzamide, N-[[4-(4-fluorophenoxy)phenyl]methyl]-2-methoxy-5-[(2S)-2-[[(4R)-2-oxo- 4-(phenylmethyl)-3-oxazolidinyl]carbonyl]butyl]-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of Benzamide, N-[[4-(4-fluorophenoxy)phenyl]methyl]-2-methoxy-5-[(2S)-2-[[(4R)-2-oxo- 4-(phenylmethyl)-3-oxazolidinyl]carbonyl]butyl]-

There total 1 articles about Benzamide, N-[[4-(4-fluorophenoxy)phenyl]methyl]-2-methoxy-5-[(2S)-2-[[(4R)-2-oxo- 4-(phenylmethyl)-3-oxazolidinyl]carbonyl]butyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 568565-86-6
4-(4-fluorophenoxyl)benzylamine hydrochloride

: 478866-20-5
[5(2S,4R)]-2-methoxy-5-[[2-(2-oxo-4-benzyloxazolidin-3-yl)carbonyl]pentyl]benzoic acid

: 311771-85-4
N-[4-(4-fluorophenoxy)phenyl]methyl-5-[3-[4-(R)-benzyl-2-oxo-1,3-oxazolidine-3-yl]-2-(S)-ethyl-3-oxopropyl]-2-methoxybenzamide

Guidance literature:: [5(2S,4R)]-2-methoxy-5-[[2-(2-oxo-4-benzyloxazolidin-3-yl)carbonyl]pentyl]benzoic acid; With chloroformic acid ethyl ester; triethylamine; In DMF (N,N-dimethyl-formamide); at 5 - 8 ℃; for 1h;

4-(4-fluorophenoxyl)benzylamine hydrochloride; In DMF (N,N-dimethyl-formamide); at 6 ℃; for 1h;

Reference yield: 78.0%

: 311771-85-4
N-[4-(4-fluorophenoxy)phenyl]methyl-5-[3-[4-(R)-benzyl-2-oxo-1,3-oxazolidine-3-yl]-2-(S)-ethyl-3-oxopropyl]-2-methoxybenzamide

: (S)-(±)-2-ethyl-3-[4-methoxy-3-[N-[(4-fluorophenoxyphenyl)methyl]carbamoyl]phenyl]propanoic acid

Guidance literature:: N-[4-(4-fluorophenoxy)phenyl]methyl-5-[3-[4-(R)-benzyl-2-oxo-1,3-oxazolidine-3-yl]-2-(S)-ethyl-3-oxopropyl]-2-methoxybenzamide; With dihydrogen peroxide; In tetrahydrofuran; water; at 8 ℃; for 0.166667h;

With lithium hydroxide; water; In tetrahydrofuran; at 8 - 10 ℃; for 2.33333h;

With sodium hydrogensulfite; In tetrahydrofuran; water; for 1.33333h;

Reference yield: 63.0%

: 311771-85-4
N-[4-(4-fluorophenoxy)phenyl]methyl-5-[3-[4-(R)-benzyl-2-oxo-1,3-oxazolidine-3-yl]-2-(S)-ethyl-3-oxopropyl]-2-methoxybenzamide

: 629647-10-5
N-[4-(3,4-Difluorophenoxy)phenylmethyl]phthalimide

: 629646-75-9
[3(2S),4R]-4-benzyl-3-(2-{3-[3-(N-{[4-(3,4-difluorophenoxy)phenyl]methyl}carbamoyl)-4-methoxyphenyl]methyl})butanoyloxazolidinone-2-one

Guidance literature:: N-[4-(3,4-Difluorophenoxy)phenylmethyl]phthalimide; With hydrazine; In ethanol; for 2h; Heating / reflux;

N-[4-(4-fluorophenoxy)phenyl]methyl-5-[3-[4-(R)-benzyl-2-oxo-1,3-oxazolidine-3-yl]-2-(S)-ethyl-3-oxopropyl]-2-methoxybenzamide; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 14h;