4H-1,4-Benzoxazine-4-carboxylic acid, 2,3-dihydro-7-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-3-methyl-, phenylmethyl ester, (3R)-

Base Information

Chemical Name:4H-1,4-Benzoxazine-4-carboxylic acid, 2,3-dihydro-7-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-3-methyl-, phenylmethyl ester, (3R)-
CAS No.:312306-16-4
Molecular Formula:C21H22N2O6
Molecular Weight:398.415
Hs Code.:
Mol file:312306-16-4.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4H-1,4-Benzoxazine-4-carboxylic acid, 2,3-dihydro-7-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-3-methyl-, phenylmethyl ester, (3R)-

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Technology Process of 4H-1,4-Benzoxazine-4-carboxylic acid, 2,3-dihydro-7-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-3-methyl-, phenylmethyl ester, (3R)-

There total 1 articles about 4H-1,4-Benzoxazine-4-carboxylic acid, 2,3-dihydro-7-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-3-methyl-, phenylmethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60456-26-0
(R)-glycidyl butyrate

: 312306-12-0
benzyl 7-{[(benzyloxy)carbonyl]amino}-3-methyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate

: 312306-16-4
benzyl (3R)-7-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-3-methyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate

: 649569-68-6
benzyl (3S)-7-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-3-methyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate

Guidance literature:: With n-butyllithium; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.07.029

Reference yield: 70.0%

: 312306-16-4
benzyl (3R)-7-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-3-methyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate

: 312306-17-5
benzyl (3R)-7-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-3-methyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate

Guidance literature:

Reference yield:

: 312306-16-4
benzyl (3R)-7-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-3-methyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate

: (R)-7-((S)-5-Aminomethyl-2-oxo-oxazolidin-3-yl)-3-methyl-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: aq. NH₃ / acetonitrile; propan-2-ol

With ammonium hydroxide; triethylamine; In dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmcl.2003.07.029