1-Boc-4-cyclohexyl-4-piperidineMethanol

Base Information

• Chemical Name: 1-Boc-4-cyclohexyl-4-piperidineMethanol
• CAS No.: 312638-87-2
• Molecular Formula: C17H31NO3
• Molecular Weight: 297.438
• Mol file: 312638-87-2.mol

Synonyms:4-Cyclohexyl-4-(hydroxymethyl)-N-(tert-butoxycarbonyl)piperidine;

Chemical Property of 1-Boc-4-cyclohexyl-4-piperidineMethanol

Chemical Property:

• Boiling Point: 400.0±15.0 °C(Predicted)
• PKA: 14.94±0.10(Predicted)
• PSA: 49.77000
• Density: 1.055±0.06 g/cm3(Predicted)
• LogP: 3.51420

Purity/Quality:

97% ^*data from raw suppliers

4-Cyclohexyl-4-(hydroxymethyl)-N-(tert-butoxycarbonyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Cyclohexyl-4-(hydroxymethyl)-N-(tert-butoxycarbonyl)piperidine, is an intermediate in the synthesis of THIQ (C380165), which is a potent, selective melanocortin subtype-4 receptor agonist.

Technology Process of 1-Boc-4-cyclohexyl-4-piperidineMethanol

There total 8 articles about 1-Boc-4-cyclohexyl-4-piperidineMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-cyclohexylpiperidine-4-carboxylic acid ethyl ester (10462-00-7) → 4-cyclohexyl-4-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester (312638-87-2)

Guidance literature:

4-cyclohexylpiperidine-4-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 90h;

di-tert-butyl dicarbonate; In methanol; triethylamine; at 20 ℃; for 4h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

Reference yield: 48.0%

di-tert-butyl dicarbonate (24424-99-5) + (4-cyclohexylpiperidin-4-yl)-methanol (624732-70-3) → 4-cyclohexyl-4-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester (312638-87-2)

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃; for 4h;

Reference yield:

methyl 1-BOC-4-cyclohexyl-4-piperidinecarboxylate (852323-82-1) → 4-cyclohexyl-4-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester (312638-87-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

upstream raw materials:

di-tert-butyl dicarbonate

(4-cyclohexylpiperidin-4-yl)-methanol

(4-phenyl-piperidin-4-yl)-methanol

Normeperidine

Downstream raw materials:

4-cyclohexyl-4-methanesulfonyloxymethylpiperidine-1-carboxylic acid tert-butyl ester

4-cyclohexyl-4-(thiazol-2-ylaminomethyl)-piperidine-1-carboxylic acid tert-butyl ester

C₂₄H₄₀N₂O₄

C₁₉H₃₂N₂O₂*ClH

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