Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, (1S,3E,5S,9S)-1-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]- 1-[(4-methoxyphenyl)methoxy]-2-propenyl]-10-[(2R,6R)-3,6-dihydro-6-(2 -oxoethyl)-2H-pyran-2-yl]-5-(methoxymethoxy)-9-methyl-7-methylene-3- decenyl ester

Base Information

Chemical Name:Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, (1S,3E,5S,9S)-1-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]- 1-[(4-methoxyphenyl)methoxy]-2-propenyl]-10-[(2R,6R)-3,6-dihydro-6-(2 -oxoethyl)-2H-pyran-2-yl]-5-(methoxymethoxy)-9-methyl-7-methylene-3- decenyl ester
CAS No.:312695-95-7
Molecular Formula:C44H59F6O12P
Molecular Weight:924.909
Hs Code.:
Mol file:312695-95-7.mol

Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-,
(1S,3E,5S,9S)-1-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-
1-[(4-methoxyphenyl)methoxy]-2-propenyl]-10-[(2R,6R)-3,6-dihydro-6-(2
-oxoethyl)-2H-pyran-2-yl]-5-(methoxymethoxy)-9-methyl-7-methylene-3-
decenyl ester

Synonyms:

Suppliers and Price of Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, (1S,3E,5S,9S)-1-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]- 1-[(4-methoxyphenyl)methoxy]-2-propenyl]-10-[(2R,6R)-3,6-dihydro-6-(2 -oxoethyl)-2H-pyran-2-yl]-5-(methoxymethoxy)-9-methyl-7-methylene-3- decenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, (1S,3E,5S,9S)-1-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]- 1-[(4-methoxyphenyl)methoxy]-2-propenyl]-10-[(2R,6R)-3,6-dihydro-6-(2 -oxoethyl)-2H-pyran-2-yl]-5-(methoxymethoxy)-9-methyl-7-methylene-3- decenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, (1S,3E,5S,9S)-1-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]- 1-[(4-methoxyphenyl)methoxy]-2-propenyl]-10-[(2R,6R)-3,6-dihydro-6-(2 -oxoethyl)-2H-pyran-2-yl]-5-(methoxymethoxy)-9-methyl-7-methylene-3- decenyl ester

There total 39 articles about Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, (1S,3E,5S,9S)-1-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]- 1-[(4-methoxyphenyl)methoxy]-2-propenyl]-10-[(2R,6R)-3,6-dihydro-6-(2 -oxoethyl)-2H-pyran-2-yl]-5-(methoxymethoxy)-9-methyl-7-methylene-3- decenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 312695-84-4
[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 7-{3-[6-(2-hydroxy-ethyl)-3,6-dihydro-2H-pyran-2-yl]-2-methyl-propyl}-1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-octa-3,7-dienyl ester

: 312695-95-7
[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-7-{2-methyl-3-[6-(2-oxo-ethyl)-3,6-dihydro-2H-pyran-2-yl]-propyl}-octa-3,7-dienyl ester

Guidance literature:: With sodium periodate; In dichloromethane; at 23 ℃;
DOI:10.1021/ja0027416

Reference yield:

: 289472-92-0
(2S)-2-(2,2-dibromo-vinyl)-4-methyl-3,6-dihydro-2H-pyran

: 312695-95-7
[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-7-{2-methyl-3-[6-(2-oxo-ethyl)-3,6-dihydro-2H-pyran-2-yl]-propyl}-octa-3,7-dienyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 23 °C

1.2: 64 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 81 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.17 h / 23 °C

3.1: 87 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C

4.1: 81 percent / Red-Al / tetrahydrofuran / -40 - -20 °C

5.1: TFA / CH₂Cl₂ / 1 h / 23 °C

6.1: 71 percent / CSA / CH₂Cl₂ / 0.5 h / 23 °C

7.1: 74 percent / DIBAL / CH₂Cl₂ / 0.5 h / -78 °C

8.1: 2,4,6-trichlorobenzoyl chloride; i-Pr₂NEt; DMAP / tetrahydrofuran; benzene / 23 °C

9.1: 32 mg / AcOH / tetrahydrofuran; H₂O / 3 h / 23 °C

10.1: 79 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.17 h / 23 °C

With dmap; n-butyllithium; 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; L-Selectride; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; water; benzene;
DOI:10.1021/jo010854h

Reference yield:

: (E)-(3S,4S)-6-Benzenesulfonyl-1-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-hex-1-ene-3,4-diol

: 312695-95-7
[bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid 1-[1-(4-methoxy-benzyloxy)-3-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-allyl]-5-methoxymethoxy-7-{2-methyl-3-[6-(2-oxo-ethyl)-3,6-dihydro-2H-pyran-2-yl]-propyl}-octa-3,7-dienyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / CSA / CH₂Cl₂ / 0.5 h / 23 °C

2: 74 percent / DIBAL / CH₂Cl₂ / 0.5 h / -78 °C

3: 2,4,6-trichlorobenzoyl chloride; i-Pr₂NEt; DMAP / tetrahydrofuran; benzene / 23 °C

4: 32 mg / AcOH / tetrahydrofuran; H₂O / 3 h / 23 °C

5: 79 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.17 h / 23 °C

With dmap; 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1021/jo010854h