Thiourea, N-[(1R,2R)-2-aminocyclohexyl]-N'-[(1S)-1-phenylethyl]-

Base Information

Chemical Name:Thiourea, N-[(1R,2R)-2-aminocyclohexyl]-N'-[(1S)-1-phenylethyl]-
CAS No.:313695-77-1
Molecular Formula:C15H23N3S
Molecular Weight:277.42800
Hs Code.:
Mol file:313695-77-1.mol

Synonyms:1-[(1R,2R)-2-aminocyclohexyl]-3-[(S)-1-phenylethyl]thiourea;1-((1R,2R)-2-Amino-cyclohexyl)-3-((S)-1-phenyl-ethyl)-thiourea;

Suppliers and Price of Thiourea, N-[(1R,2R)-2-aminocyclohexyl]-N'-[(1S)-1-phenylethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Thiourea, N-[(1R,2R)-2-aminocyclohexyl]-N'-[(1S)-1-phenylethyl]-

Chemical Property:

PSA：82.17000
LogP:3.96370

Purity/Quality:: >95%,>98%e.e. ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Thiourea, N-[(1R,2R)-2-aminocyclohexyl]-N'-[(1S)-1-phenylethyl]-

There total 4 articles about Thiourea, N-[(1R,2R)-2-aminocyclohexyl]-N'-[(1S)-1-phenylethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 24277-43-8
(S)-1-phenylethyl isothiocyanate

: 313695-77-1
(1R,2R)-1-(2-aminocyclohexyl)-3-[(S)-1-phenylethyl]thiourea

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetasy.2009.06.003

Reference yield: 68.0%

: (R,R)-1,2-cyclohexanediamine hydrochloride

: 24277-43-8
(S)-1-phenylethyl isothiocyanate

: 313695-77-1
(1R,2R)-1-(2-aminocyclohexyl)-3-[(S)-1-phenylethyl]thiourea

Guidance literature:: (R,R)-1,2-cyclohexanediamine hydrochloride; With potassium hydroxide; In dichloromethane; isopropyl alcohol; for 0.5h;

(S)-1-phenylethyl isothiocyanate; In dichloromethane; isopropyl alcohol;
DOI:10.1039/c9ob01893j

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 313695-77-1
(1R,2R)-1-(2-aminocyclohexyl)-3-[(S)-1-phenylethyl]thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 1 h / 20 °C

2: 2-chloro-1,3-dimethylimidazolinium chloride / CH₂Cl₂ / 1 h / 20 °C

3: 54 percent / CH₂Cl₂ / 120 h / 20 °C

With 2-chloro-1,3-dimethylimidazolinium chloride; In dichloromethane; 1: Substitution / 2: Elimination / 3: Substitution;
DOI:10.1021/jo000745n