2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-HYDROXYMETHYL THIAZOLE

Base Information

• Chemical Name: 2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-HYDROXYMETHYL THIAZOLE
• CAS No.: 317319-27-0
• Molecular Formula: C12H9F4NOS
• Molecular Weight: 291.26500
• Hs Code.: 2934100090
• Mol file: 317319-27-0.mol

Synonyms:(2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methanol;{2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methanol;5-(Hydroxymethyl)-2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazole;

Chemical Property of 2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-HYDROXYMETHYL THIAZOLE

Chemical Property:

• Melting Point: 159-161
• PSA: 61.36000
• LogP: 3.76870
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-hydroxymethylThiazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-hydroxymethyl Thiazole (cas# 317319-27-0) is a compound useful in organic synthesis.

Technology Process of 2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-HYDROXYMETHYL THIAZOLE

There total 2 articles about 2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-HYDROXYMETHYL THIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl 4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole-5-carboxylate (317319-21-4) → 5-hydroxymethyl-4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole (317319-27-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0960-894X(03)00207-5

Reference yield:

3-fluoro-4-(trifluoromethyl)thiobenzamide (317319-16-7) → 5-hydroxymethyl-4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole (317319-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / ethanol / Heating

2: 87 percent / LiAlH₄ / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; ethanol;

DOI:10.1016/S0960-894X(03)00207-5

Reference yield: 100.0%

5-hydroxymethyl-4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole (317319-27-0) → 5-chloromethyl-4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole (317319-33-8)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/S0960-894X(03)00207-5

upstream raw materials:

ethyl 4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole-5-carboxylate

3-fluoro-4-(trifluoromethyl)thiobenzamide

Downstream raw materials:

5-chloromethyl-4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]thiazole

Refernces

• 1、 Sznaidman, Marcos L.,Haffner, Curt D.,Maloney, Patrick R.,Fivush, Adam,Chao, Esther,Goreham, Donna,Sierra, Michael L.,LeGrumelec, Christelle,Xu, H. Eric,Montana, Valerie G.,Lambert, Millard H.,Willson, Timothy M.,Oliver Jr., William R.,Sternbach, Daniel D.. "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity". . p. 1517 - 1521. Retrieved 2007/10/03.