4-phenyl-5,6-dihydro-2H-p...

Base Information

• Chemical Name: 4-phenyl-5,6-dihydro-2H-p...
• CAS No.: 3174-81-0
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Hs Code.: 2932999099
• Mol file: 3174-81-0.mol

Synonyms:4-phenyl-3,6-dihydro-2H-pyran;

Chemical Property of 4-phenyl-5,6-dihydro-2H-p...

Chemical Property:

• Melting Point: 61-62 °C
• Boiling Point: 72-77 °C(Press: 0.1 Torr)
• PSA: 9.23000
• Density: 1.047±0.06 g/cm3(Predicted)
• LogP: 2.49030

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-phenyl-5,6-dihydro-2H-pyran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-phenyl-5,6-dihydro-2H-p...

There total 36 articles about 4-phenyl-5,6-dihydro-2H-p... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) + bromobenzene (108-86-1,52753-63-6) → 4-phenyl-5,6-dihydro-2H-pyran (3174-81-0)

Guidance literature:

Tetrahydro-4H-pyran-4-one; bromobenzene; With iodine; magnesium; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

With toluene-4-sulfonic acid; In toluene; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/ja509766f

Reference yield: 95.0%

2-phenyl-2-vinyloxetane (1392318-50-1) → 4-phenyl-5,6-dihydro-2H-pyran (3174-81-0)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201201367

Reference yield: 80.0%

bromobenzene (108-86-1,52753-63-6) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyran (287944-16-5) → 4-phenyl-5,6-dihydro-2H-pyran (3174-81-0)

Guidance literature:

With triethylamine; In water; at 95 ℃; Flow reactor; Green chemistry;

DOI:10.1039/d1gc02461b

upstream raw materials:

4-methyl-4-phenyl-1,3-dioxane

pentanal

benzaldehyde

acetaldehyde

Refernces

• 1、 Music, Arif,Baumann, Andreas N.,Boser, Florian,Müller, Nicolas,Matz, Florian,Jagau, Thomas C.,Didier, Dorian. "Photocatalyzed Transition-Metal-Free Oxidative Cross-Coupling Reactions of Tetraorganoborates**". supporting information. p. 4322 - 4326. Retrieved 2021/02/11.
• 2、 Chang, Jim,Gallou, Fabrice,Lipshutz, Bruce H.,Plummer, Scott,Robinson, Richard I.,Smith, Marie,Wood, Alex B.. "Continuous slurry plug flow Fe/ppm Pd nanoparticle-catalyzed Suzuki-Miyaura couplings in water utilizing novel solid handling equipment". supporting information. p. 7724 - 7730. Retrieved 2021/10/12.