2H-Isoindole-2-hexanoyl chloride, 1,3-dihydro-1,3-dioxo-

Base Information

• Chemical Name: 2H-Isoindole-2-hexanoyl chloride, 1,3-dihydro-1,3-dioxo-
• CAS No.: 31968-60-2
• Molecular Formula: C14H14ClNO3
• Molecular Weight: 279.723
• Mol file: 31968-60-2.mol

Synonyms:

Chemical Property of 2H-Isoindole-2-hexanoyl chloride, 1,3-dihydro-1,3-dioxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Isoindole-2-hexanoyl chloride, 1,3-dihydro-1,3-dioxo-

There total 1 articles about 2H-Isoindole-2-hexanoyl chloride, 1,3-dihydro-1,3-dioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 6-phthalimidohexanoyl chloride (31968-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 6 h / 170 °C

2: 100 percent / oxalyl chloride / CH₂Cl₂ / 6 h / Heating

With oxalyl dichloride; In dichloromethane;

DOI:10.1002/ejoc.200601067

Reference yield: 70.0%

6-phthalimidohexanoyl chloride (31968-60-2) + (R)-4-(1-methylethyl)-5,5-diphenyl-1,3-oxazolidin-2-one (191090-32-1) → (R)-4-(1-methylethyl)-3-(1-oxo-5-phthalimidohexanoyl)-5,5-diphenyloxazolidin-2-one (357271-57-9)

Guidance literature:

(R)-4-(1-methylethyl)-5,5-diphenyl-1,3-oxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; at 0 ℃;

6-phthalimidohexanoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; Further stages.;

DOI:10.1021/jm010816q

Reference yield: 70.0%

6-phthalimidohexanoyl chloride (31968-60-2) + [5-(4-Fluoro-phenyl)-5-pyridin-2-yl-pentyl]-[2-(1H-imidazol-4-yl)-ethyl]-amine → 6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-hexanoic acid [5-(4-fluoro-phenyl)-5-pyridin-2-yl-pentyl]-[2-(1H-imidazol-4-yl)-ethyl]-amide

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1002/ardp.19973301104

upstream raw materials:

phthalic anhydride

Downstream raw materials:

6-[6-(6-amino-hexanoylamino)-hexanoylamino]-hexanoic acid

6-phthalimido-hexanoic acid anilide

methylene chloride

[6-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-hexanoyl]-phosphonic acid dimethyl ester