Bapta-AM

Base Information

• Chemical Name: Bapta-AM
• CAS No.: 126150-97-8
• Molecular Formula: C34H40N2O18
• Molecular Weight: 764.694
• Hs Code.: 2921490090
• European Community (EC) Number: 634-129-4
• DSSTox Substance ID: DTXSID60274361
• Nikkaji Number: J444.178H
• Wikidata: Q27164448
• ChEMBL ID: CHEMBL1608767
• Mol file: 126150-97-8.mol

Synonyms:1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester;1,2-bis(o-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester;BAPTA-AM

Chemical Property of Bapta-AM

Chemical Property:

• Appearance/Colour: Off-white to light yellow solid
• Vapor Pressure: 2.42E-25mmHg at 25°C
• Melting Point: 86-90 °C
• Refractive Index: 1.551
• Boiling Point: 796.086 °C at 760 mmHg
• PKA: 1.69±0.50(Predicted)
• Flash Point: 435.257 °C
• PSA: 235.34000
• Density: 1.35 g/cm³
• LogP: 1.01240
• Storage Temp.: −20°C
• Solubility.: Soluble in chloroform, dimethyl sulfoxide
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 20
• Rotatable Bond Count: 31
• Exact Mass: 764.22761243
• Heavy Atom Count: 54
• Complexity: 1100

Purity/Quality:

98%,99%, ^*data from raw suppliers

BAPTA-AM ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
• Description: BAPTA-AM is a selective, membrane-permeable calcium chelator. BAPTA-AM (126150-97-8) is a selective cell permeable Ca2+ chelator. It is a widely used intracellular calcium sponge.1,2 Rapidly taken up by cells where it is irreversibly hydrolyzed to BAPTA by intracellular esterases. Pretreatment of cells with BAPTA-AM inhibits thapsigargin-induced responses.3
• Uses: A cell permeable derivative of BAPTA which is widely used as an intracellular calcium sponge. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9 BAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9 A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores. BAPTA is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases. It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling. It can also be used in animals. BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).