2H-Pyran, tetrahydro-2-(4-methoxyphenoxy)-

Base Information

• Chemical Name: 2H-Pyran, tetrahydro-2-(4-methoxyphenoxy)-
• CAS No.: 20443-88-3
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• DSSTox Substance ID: DTXSID70942620
• Nikkaji Number: J853.467E
• Mol file: 20443-88-3.mol

Synonyms:2-(4-methoxyphenoxy)tetrahydro-2H-pyran;AI3-30005;20443-88-3;2H-Pyran, tetrahydro-2-(4-methoxyphenoxy)-;2-(4-methoxyphenoxy)oxane;SCHEMBL813805;DTXSID70942620;WFWSREBPXRRQQR-UHFFFAOYSA-N

Chemical Property of 2H-Pyran, tetrahydro-2-(4-methoxyphenoxy)-

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 208.109944368
• Heavy Atom Count: 15
• Complexity: 176

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)OC2CCCCO2

Technology Process of 2H-Pyran, tetrahydro-2-(4-methoxyphenoxy)-

There total 5 articles about 2H-Pyran, tetrahydro-2-(4-methoxyphenoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-methoxy-phenol (150-76-5) → 2-(4-methoxyphenoxy)tetrahydro-2H-pyran (20443-88-3)

Guidance literature:

With cerium(III) chloride; sodium iodide; at 25 ℃; for 29h;

DOI:10.1002/ejoc.200500780

Reference yield:

1-[2-(tetrahydropyranyl)oxy]-4-tert-butylbenzene (17356-00-2) → 2-(4-methoxyphenoxy)tetrahydro-2H-pyran (20443-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / neat (no solvent, gas phase) / 0.15 h / 360 °C / Gas phase

2: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C

With toluene-4-sulfonic acid; toluene; In dichloromethane;

DOI:10.1002/poc.3778

Reference yield:

2-phenoxytetrahydropyran (4203-50-3) → 2-(4-methoxyphenoxy)tetrahydro-2H-pyran (20443-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / neat (no solvent, gas phase) / 0.07 h / 371.6 °C / Gas phase

2: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C

With toluene-4-sulfonic acid; toluene; In dichloromethane;

DOI:10.1002/poc.3778

upstream raw materials:

3,4-dihydro-2H-pyran

4-methoxy-phenol

2-phenoxytetrahydropyran

1-[2-(tetrahydropyranyl)oxy]-4-tert-butylbenzene

Downstream raw materials:

1-<2-(2-tetrahydropyranyloxy)-5-methoxyphenyl>-3-methyl-2-buten-1-ol

1-<2-(2-tetrahydropyranyloxy)-5-methoxyphenyl>-3,7-dimethyl-2,6-octadien-1-ol

4-methoxy-phenol

2-(4-methoxy-2-methyl-phenoxy)tetrahydro-2H-pyran