Ethyl 2-Methyl-2-(5-chloro-2-pyridyloxy)propionate

Base Information

Chemical Name:Ethyl 2-Methyl-2-(5-chloro-2-pyridyloxy)propionate
CAS No.:32177-89-2
Molecular Formula:C₁₁H₁₄ClNO₃
Molecular Weight:243.69
Hs Code.:
DSSTox Substance ID:DTXSID30582642
Wikidata:Q82474127
Mol file:32177-89-2.mol

Synonyms:32177-89-2;Ethyl 2-Methyl-2-(5-chloro-2-pyridyloxy)propionate;SCHEMBL3374716;DTXSID30582642;COOWRSNQEDDDBI-UHFFFAOYSA-N;Ethyl 2-[(5-chloropyridin-2-yl)oxy]-2-methylpropanoate

Suppliers and Price of Ethyl 2-Methyl-2-(5-chloro-2-pyridyloxy)propionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Ethyl 2-Methyl-2-(5-chloro-2-pyridyloxy)propionate

Chemical Property:

Vapor Pressure:0.001mmHg at 25°C
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:243.0662210
Heavy Atom Count:16
Complexity:245

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C)(C)OC1=NC=C(C=C1)Cl

Technology Process of Ethyl 2-Methyl-2-(5-chloro-2-pyridyloxy)propionate

There total 1 articles about Ethyl 2-Methyl-2-(5-chloro-2-pyridyloxy)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 600-00-0
ethyl 2-bromoisobutyrate

: 4214-79-3
5-chloro-2-pyridinol

: 32177-89-2
ethyl 2-methyl-2-(5-chloro-2-pyridyloxy)propionate

Guidance literature:: With caesium carbonate; In acetonitrile; at 50 ℃;
DOI:10.1021/jm060996+

Reference yield:

: 32177-89-2
ethyl 2-methyl-2-(5-chloro-2-pyridyloxy)propionate

: C₂₈H₂₉ClFN₃O₃

Guidance literature:: Multi-step reaction with 2 steps

1: aq. sodium hydroxide / acetonitrile / 50 °C

2: PyBop; N-methylmorpholine / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dichloromethane; acetonitrile;
DOI:10.1021/jm070131b

Reference yield:

: 32177-89-2
ethyl 2-methyl-2-(5-chloro-2-pyridyloxy)propionate

: N-(1S,2S)-{2-(3-cyanophenyl)-3-[4-(2-fluoroethoxy)phenyl]-1-methylpropyl}-2-(5-cyano-2-pyridyloxy)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: aq. sodium hydroxide / acetonitrile / 50 °C

2: CH₂Cl₂; methanol / 0.25 h / 20 °C

3: tributyltin chloride; tris(dibenzylideneacetone) dipalladium; tri(tert-butyl)phosphine / acetonitrile / 80 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; H₂O / 20 °C

5: PyBop; N-methylmorpholine / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; lithium hydroxide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; tributyltin chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm070131b