Lobatrienolide

Base Information

Chemical Name:Lobatrienolide
CAS No.:139579-31-0
Molecular Formula:C₂₀H₃₀O₃
Molecular Weight:318.456
Hs Code.:
Mol file:139579-31-0.mol

Synonyms:

Suppliers and Price of Lobatrienolide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Lobatrienolide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Lobatrienolide

There total 19 articles about Lobatrienolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (R)-6-(1-Hydroxy-1-methyl-ethyl)-3-((1S,3R,4R)-3-isopropenyl-4-methyl-4-vinyl-cyclohexyl)-4-phenylselanyl-tetrahydro-pyran-2-one

: 139579-31-0
lobatrienolide

Guidance literature:: With water; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 12h;
DOI:10.1039/a809983i

Reference yield:

: lobatriene

: 139579-31-0
lobatrienolide

Guidance literature:: With oxygen; methylene blue; In dichloromethane; benzene; for 62h; Irradiation;
DOI:10.1246/cl.1992.33

Reference yield:

: 149404-74-0
(4R,5R)-1-Acetoxy-4-isopropenyl-5-methyl-5-vinylcyclohex-1-ene

: 139579-31-0
lobatrienolide

Guidance literature:: Multi-step reaction with 14 steps

1: 98 percent / K₂CO₃ / methanol

2: LDA, HMPA / tetrahydrofuran; hexane / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 4 h

3: 81 percent / LiAlH₄ / tetrahydrofuran / 2 h / -50 °C

4: 87 percent / imidazole / dimethylformamide / 1 h

5: 1.) BuLi / 1.) THF, hexane, -78 deg C, 30 min; -78 deg C, 30 min, 2.) THF, hexane, 50 min

6: AIBN, HSnBu₃ / toluene / 0.5 h / 90 °C

7: Bu₄NF / tetrahydrofuran / 6 h

8: CrO₃, H₂SO₄, H₂O / acetone

9: diethyl ether / 0 °C

10: 98 percent / LDA, HMPA / tetrahydrofuran; hexane / 1.) -78 to 0 deg C, 2 h, 2.) -78 deg C, 2 h

11: PPTS, H₂O / methanol / 9 h / Heating

12: 80 percent / p-TsOH / CH₂Cl₂ / 8 h / Heating

13: 63 percent / LDA, HMPA / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) -78 to -30 deg C, 3 h

14: 70 percent / H₂O₂, H₂O / tetrahydrofuran / 12 h / 0 °C

With 1H-imidazole; chromium(VI) oxide; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; 2,2'-azobis(isobutyronitrile); sulfuric acid; tetrabutyl ammonium fluoride; water; dihydrogen peroxide; tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1039/a809983i