2-Chloro-5-(hydrazinecarbonyl)benzenesulfonamide

Base Information

• Chemical Name: 2-Chloro-5-(hydrazinecarbonyl)benzenesulfonamide
• CAS No.: 5378-62-1
• Molecular Formula: C7H8ClN3O3S
• Molecular Weight: 249.678
• Hs Code.: 2935009090
• European Community (EC) Number: 859-627-0
• DSSTox Substance ID: DTXSID90368520
• Wikidata: Q82155109
• Mol file: 5378-62-1.mol

Synonyms:5378-62-1;2-chloro-5-(hydrazinecarbonyl)benzenesulfonamide;2-chloro-5-(hydrazinocarbonyl)benzenesulfonamide;2-chloro-5-(hydrazinecarbonyl)benzene-1-sulfonamide;3-(aminosulfonyl)-4-chloroBenzoic acid hydrazide;SCHEMBL1272484;DTXSID90368520;XKQKCGDIIVQYKP-UHFFFAOYSA-N;MFCD04624844;3-sulfamoyl-4-chlorobenzoic hydrazide;3-amino sulfonyl-4-chlorobenzhydrazide;3-aminosulfonyl-4-chloro-benzhydrazide;AKOS004123185;CS-0220556;FT-0736199;EN300-06935;A918048;Z56947586

Chemical Property of 2-Chloro-5-(hydrazinecarbonyl)benzenesulfonamide

Chemical Property:

• Melting Point: 210-212 °C
• PKA: 9.39±0.60(Predicted)
• PSA: 127.15000
• Density: 1.581g/cm³
• LogP: 2.64710
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 248.9974900
• Heavy Atom Count: 15
• Complexity: 340

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-5-(hydrazinocarbonyl)benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1C(=O)NN)S(=O)(=O)N)Cl
• Uses: 2-Chloro-5-(hydrazinocarbonyl)benzenesulfonamide is an intermediate in the synthesis of Besulpamide (B319750) which is an antihypertensive agent. It also exhibits diuretic activity in rats and dogs.

Technology Process of 2-Chloro-5-(hydrazinecarbonyl)benzenesulfonamide

There total 5 articles about 2-Chloro-5-(hydrazinecarbonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-sulfamoyl-4-chlorobenzoic acid ethyl ester (1211-77-4) → 3-sulfamoyl-4-chlorobenzoic acid hydrazide (5378-62-1)

Guidance literature:

at 70 - 75 ℃; for 0.166667h;

DOI:10.1007/BF02464263

Reference yield:

3-(aminosulfonyl)-4-chlorobenzoyl chloride (70049-77-3) → 3-sulfamoyl-4-chlorobenzoic acid hydrazide (5378-62-1)

Guidance literature:

With hydrazine; In water;

Reference yield:

4-chloro-3-sulfamoylbenzoic acid methyl ester (1208-40-8) → 3-sulfamoyl-4-chlorobenzoic acid hydrazide (5378-62-1)

Guidance literature:

With hydrazine; In water; at 60 ℃;

DOI:10.1016/j.bmc.2008.05.076

upstream raw materials:

4-Chlor-3-sulfamoyl-benzoesaeure-cyanmethylester

3-sulfamoyl-4-chlorobenzoic acid ethyl ester

3-(aminosulfonyl)-4-chlorobenzoyl chloride

4-chloro-3-sulfamoylbenzoic acid methyl ester

Downstream raw materials:

N-(2-chloro-5-[1,3,4]oxadiazol-2-yl-benzenesulfonyl)-formimidic acid ethyl ester

2-Chloro-5-[1-(3-nitro-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-benzenesulfonamide

2-Chloro-5-[1-(4-nitro-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-benzenesulfonamide

2-Chloro-5-[1-phenyl-meth-(E)-ylidene-hydrazinocarbonyl]-benzenesulfonamide